1-Boc-4-(2-氧代丙基)哌啶合成路线 （共 4 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol P=2585.81 Torr; 5 h;
参考文献
Walker, Daniel P.; Acker, Brad A.; Jacobsen, E. Jon; Wishka, Donn G.
Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 1 p. 247 - 257
反应条件
in tetrahydrofuran; diethyl ether T=-78 - 0°C; 1.83333 h;
参考文献
EP1386920 A1, ;
Page 50 ;
反应条件
1: Sodium hydride / tetrahydrofuran / 2.67 h / 0 - 20 °C / Heating / reflux 2: hydrogen / palladium 10 on activated carbon / ethanol / 5 h / 2585.81 Torr View Scheme
反应条件
1: chloro-trimethyl-silane; trimethylphenylammonium monobromide; lithium hexamethyldisilazane / tetrahydrofuran / 1.33 h / -78 - 0 °C
2: dichloromethane / 0.5 h / 0 °C
3: N-ethyl-N,N-diisopropylamine / acetonitrile
View Scheme
参考文献
Walker, Daniel Patrick; Piotrowski, David W.; Jacobsen, Eric Jon; Acker, Brad A.; Myers, Jason K.; Groppi JR., Vincent E.
Patent: US2003/236279 A1, 2003 ;
