6-(4-羧基苯基)-8-溴-1,7-萘啶合成路线 （共 6 条）
反应条件
phosphorus tribromide in N,N-dimethyl-formamide T=100°C; 0.5 h;
参考文献
Hersperger, Rene; Dawson, Janet; Mueller, Thomas
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 233 - 235
反应条件
1: 75 percent / Pd(dba)2; PPh3; 2 N aq. Na2CO3 / dimethylformamide / 2 h / 80 °C 2: 73 percent / PBr3 / dimethylformamide / 0.5 h / 100 °C View Scheme
参考文献
Hersperger, Rene; Dawson, Janet; Mueller, Thomas
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 233 - 235
反应条件
1: 63 percent / Na / 16 h / 20 °C 2: 46 percent / aq. NaNO2 / 3 h / 0 °C 3: 75 percent / Pd(dba)2; PPh3; 2 N aq. Na2CO3 / dimethylformamide / 2 h / 80 °C 4: 73 percent / PBr3 / dimethylformamide / 0.5 h / 100 °C View Scheme
参考文献
Hersperger, Rene; Dawson, Janet; Mueller, Thomas
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 233 - 235
反应条件
1: 46 percent / aq. NaNO2 / 3 h / 0 °C 2: 75 percent / Pd(dba)2; PPh3; 2 N aq. Na2CO3 / dimethylformamide / 2 h / 80 °C 3: 73 percent / PBr3 / dimethylformamide / 0.5 h / 100 °C View Scheme
参考文献
Hersperger, Rene; Dawson, Janet; Mueller, Thomas
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 233 - 235
反应条件
1: 75 percent / Pd(dba)2; PPh3; 2 N aq. Na2CO3 / dimethylformamide / 2 h / 80 °C 2: 73 percent / PBr3 / dimethylformamide / 0.5 h / 100 °C View Scheme
参考文献
Hersperger, Rene; Dawson, Janet; Mueller, Thomas
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 233 - 235
反应条件
sodium carbonate; tris-(o-tolyl)phosphine; bis(dibenzylideneacetone)-palladium(0) in N,N-dimethyl-formamide
T=110°C; Suzuki coupling; 2 h;
参考文献
Hersperger, Rene; Dawson, Janet; Mueller, Thomas
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 233 - 235
