2-氨基-4-甲氧基苯酚合成路线 （共 33 条）
反应条件
potassium carbonate in acetone
20 h; Heating;
参考文献
Touzeau, Frederique; Arrault, Axelle; Guillaumet, Gerald; Scalbert, Elizabeth; Pfeiffer, Bruno; Rettori, Marie-Claire; Renard, Pierre; Merour, Jean-Yves
Journal of Medicinal Chemistry, 2003 , vol. 46, # 10 p. 1962 - 1979
反应条件
potassium carbonate in acetone
18 h; Heating;
参考文献
Mayer; Arrault; Guillaumet; Merour
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 1 p. 221 - 225
反应条件
in toluene
2 h; Heating;
参考文献
Loev, Bernard; Jones, Howard; Brown, Richard E.; Huang, Fu-chih; Khandawala, Atul; et. al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 24 - 27
反应条件
1: KOH / ethanol / Heating
2: PCl5 / toluene / Heating
View Scheme
参考文献
Lazer, Edward S.; Miao, Clara K.; Wong, Hin-Chor; Sorcek, Ronald; Spero, Denice M.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 7 p. 913 - 923
反应条件
1-methyl-pyrrolidin-2-one; 1,8-diazabicyclo[5.4.0]undec-7-ene
T=180°C; 0.05 h; microwave irradiation;
参考文献
Dai, Wei-Min; Wang, Xuan; Ma, Chen
Tetrahedron, 2005 , vol. 61, # 28 p. 6879 - 6885
反应条件
1: aq. HCl
2: PbO / methanol / Heating
View Scheme
参考文献
Sam,J.; Plampin,J.N.
Journal of Pharmaceutical Sciences, 1964 , vol. 53, p. 538 - 544
反应条件
(i) MeOH, (ii) H2O; Multistep reaction;
参考文献
Sam,J.; Plampin,J.N.
Journal of Pharmaceutical Sciences, 1964 , vol. 53, p. 538 - 544
反应条件
triethylamine in dichloromethane
T=0 - 20°C; 1.16667 h; Inert atmosphere;
参考文献
YALE UNIVERSITY; JORGENSEN, William; BUCALA, Richard, J.
Patent: WO2010/21693 A2, 2010 ;
Location in patent: Page/Page column 34 ;
反应条件
in tetrahydrofuran
T=20°C; 1 h;
参考文献
MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
Patent: US2010/280030 A1, 2010 ;
Location in patent: Page/Page column 19 ;
反应条件
1: (i) MeOH, (ii) H2O
2: aq. HCl / Heating
View Scheme
参考文献
Sam,J.; Plampin,J.N.
Journal of Pharmaceutical Sciences, 1964 , vol. 53, p. 538 - 544
