N-苯甲酰基-5'-O-[二(4-甲氧基苯基)苯基甲基]-3'-脱氧-腺苷 2'-[2-氰基乙基二(1-甲基乙基)亚磷酰胺]合成路线 （共 9 条）
反应条件
1H-tetrazole in acetonitrile T=20°C; 2 h;
参考文献
Charubala, Ramamurthy; Pfleidere, Wolfgang; Suhadolnik, Robert J.; Iacono, Kathryn T.; Muto, Nicholas F.; Homan, Joseph W.; Martinand-Mari, Camille; Horvath, Susan E.; Henderson, Earl E.; Steele, Amber; Rogers, Thomas J.
Helvetica Chimica Acta, 2002 , vol. 85, # 8 p. 2284 - 2299
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane 1 h; Ambient temperature;
参考文献
Arslan, Tuncer; Abraham, Anil T.; Hecht, Sidney M.
Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 515 - 530
反应条件
1.1: pyridine; Huenig's base / dioxane / 3 h / 20 °C 1.2: 69 percent / pyridine 2.1: 90 percent / 1H-tetrazole / acetonitrile / 2 h / 20 °C View Scheme
参考文献
Arslan, Tuncer; Abraham, Anil T.; Hecht, Sidney M.
Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 515 - 530
反应条件
1.1: pyridine; Huenig's base / dioxane / 3 h / 20 °C 1.2: 69 percent / pyridine 2.1: 90 percent / 1H-tetrazole / acetonitrile / 2 h / 20 °C View Scheme
参考文献
Charubala, Ramamurthy; Pfleidere, Wolfgang; Suhadolnik, Robert J.; Iacono, Kathryn T.; Muto, Nicholas F.; Homan, Joseph W.; Martinand-Mari, Camille; Horvath, Susan E.; Henderson, Earl E.; Steele, Amber; Rogers, Thomas J.
Helvetica Chimica Acta, 2002 , vol. 85, # 8 p. 2284 - 2299
反应条件
1.1: pyridine; Huenig's base / dioxane / 3 h / 20 °C 1.2: 69 percent / pyridine 2.1: 90 percent / 1H-tetrazole / acetonitrile / 2 h / 20 °C View Scheme
参考文献
Charubala, Ramamurthy; Pfleidere, Wolfgang; Suhadolnik, Robert J.; Iacono, Kathryn T.; Muto, Nicholas F.; Homan, Joseph W.; Martinand-Mari, Camille; Horvath, Susan E.; Henderson, Earl E.; Steele, Amber; Rogers, Thomas J.
Helvetica Chimica Acta, 2002 , vol. 85, # 8 p. 2284 - 2299
反应条件
1: 69 percent / pyridine / 12 h / 0 °C 2: 70 percent / iPr2NEt / CH2Cl2 / 1 h / Ambient temperature View Scheme
参考文献
Arslan, Tuncer; Abraham, Anil T.; Hecht, Sidney M.
Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 515 - 530
反应条件
1: 61 percent / TMSOTf / acetonitrile / 12 h / 55 °C 2: 77 percent / NaOH / ethanol; pyridine / 0.08 h / Ambient temperature 3: 1.) NaIO4, 2.) NaBH4 / 1.) THF, H2O, room temperature, 2 h, 2.) MeOH, room temperature, 30 min 4: 69 percent / pyridine / 12 h / 0 °C 5: 70 percent / iPr2NEt / CH2Cl2 / 1 h / Ambient temperature View Scheme
参考文献
Arslan, Tuncer; Abraham, Anil T.; Hecht, Sidney M.
Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 515 - 530
反应条件
1: 1.) NaIO4, 2.) NaBH4 / 1.) THF, H2O, room temperature, 2 h, 2.) MeOH, room temperature, 30 min 2: 69 percent / pyridine / 12 h / 0 °C 3: 70 percent / iPr2NEt / CH2Cl2 / 1 h / Ambient temperature View Scheme
参考文献
Arslan, Tuncer; Abraham, Anil T.; Hecht, Sidney M.
Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 515 - 530
反应条件
1: 77 percent / NaOH / ethanol; pyridine / 0.08 h / Ambient temperature 2: 1.) NaIO4, 2.) NaBH4 / 1.) THF, H2O, room temperature, 2 h, 2.) MeOH, room temperature, 30 min 3: 69 percent / pyridine / 12 h / 0 °C 4: 70 percent / iPr2NEt / CH2Cl2 / 1 h / Ambient temperature View Scheme
参考文献
Arslan, Tuncer; Abraham, Anil T.; Hecht, Sidney M.
Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 515 - 530
