2-氯-N-(2,6-二氯苯基)-N-(4-甲氧基苯基) 乙酰胺合成路线 （共 11 条）
反应条件
in methanol; chloroacetyl chloride
参考文献
American Home Products Corporation
Patent: US5021576 A1, 1991 ;
US 5021576 A
反应条件
1: 59 percent / rac-BINAP; Pd(OAc)2; Cs2CO3 / toluene / 20 h / Heating 2: 1.5 h / 105 °C View Scheme
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
反应条件
1: 59 percent / rac-BINAP; Pd(OAc)2; Cs2CO3 / toluene / 20 h / Heating 2: 1.5 h / 105 °C View Scheme
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
反应条件
in isopropyl alcohol; toluene T=80 - 100°C; Substitution; 4 h;
参考文献
Wang, Jian Ta; Wang, Ying; Zhang, Ji Quan; Cui, Xing; Zhang, Yi; Zhu, Gao Feng; Tang, Lei
Chinese Chemical Letters, 2011 , vol. 22, # 4 p. 409 - 412
反应条件
1.1: potassium carbonate / acetone / Reflux 2.1: hydrogenchloride; iron / ethanol; water / Reflux 3.1: sulfuric acid / tetrahydrofuran / 0 °C 3.2: 0.5 h / 0 °C 3.3: 3 h / 0 °C / Reflux 4.1: copper(l) iodide; copper; potassium carbonate / 1-methyl-pyrrolidin-2-one / 40 h / 160 °C 5.1: 1.5 h / 105 °C View Scheme
参考文献
Wang, Jian Ta; Wang, Ying; Zhang, Ji Quan; Cui, Xing; Zhang, Yi; Zhu, Gao Feng; Tang, Lei
Chinese Chemical Letters, 2011 , vol. 22, # 4 p. 409 - 412
反应条件
1.1: hydrogenchloride; iron / ethanol; water / Reflux 2.1: sulfuric acid / tetrahydrofuran / 0 °C 2.2: 0.5 h / 0 °C 2.3: 3 h / 0 °C / Reflux 3.1: copper(l) iodide; copper; potassium carbonate / 1-methyl-pyrrolidin-2-one / 40 h / 160 °C 4.1: 1.5 h / 105 °C View Scheme
参考文献
Wang, Jian Ta; Wang, Ying; Zhang, Ji Quan; Cui, Xing; Zhang, Yi; Zhu, Gao Feng; Tang, Lei
Chinese Chemical Letters, 2011 , vol. 22, # 4 p. 409 - 412
反应条件
1.1: sulfuric acid / tetrahydrofuran / 0 °C 1.2: 0.5 h / 0 °C 1.3: 3 h / 0 °C / Reflux 2.1: copper(l) iodide; copper; potassium carbonate / 1-methyl-pyrrolidin-2-one / 40 h / 160 °C 3.1: 1.5 h / 105 °C View Scheme
参考文献
Graevskaya; Azimov; Ryabova; Alekseeva; Anisimova; Syubaev; Granik
Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 1 p. 41 - 44
反应条件
1: 62 percent / TiCl4 / toluene / 48 h / 20 °C 2: (CH3CH2)3N / dimethylformamide / 6 h / 110 °C 3: toluene; propan-2-ol / 4 h / 80 - 100 °C View Scheme
参考文献
Graevskaya; Azimov; Ryabova; Alekseeva; Anisimova; Syubaev; Granik
Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 1 p. 41 - 44
反应条件
1: (CH3CH2)3N / dimethylformamide / 6 h / 110 °C 2: toluene; propan-2-ol / 4 h / 80 - 100 °C View Scheme
参考文献
Graevskaya; Azimov; Ryabova; Alekseeva; Anisimova; Syubaev; Granik
Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 1 p. 41 - 44
反应条件
aluminium trichloride T=200 - 215°C; Cyclization; demethylation; Friedel-Crafts reaction; 4 h;
参考文献
Graevskaya; Azimov; Ryabova; Alekseeva; Anisimova; Syubaev; Granik
Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 1 p. 41 - 44
