1: trifluoroacetic acid / CH2Cl2 / 1.5 h / Ambient temperature 2: toluene / 0.5 h / Heating 3: 65 percent / 0.1percent aq. K2HPO4/KH2PO4 buffer pH=6.0 / 240 h / 30 °C / Phaeocreopsis sp. JSM 1880 4: 1.) Ph3P, diethylazodicarboxylate, diphenylphosphoryl azide, 2.) LiAlH4 / 1.) THF, RT, 24 h, 2.) THF, reflux, 1 h View Scheme

1: trifluoroacetic acid / CH2Cl2 / 1.5 h / Ambient temperature 2: toluene / 0.5 h / Heating View Scheme

1: trifluoroacetic acid / CH2Cl2 / 1.5 h / Ambient temperature 2: toluene / 0.5 h / Heating 3: 65 percent / 0.1percent aq. K2HPO4/KH2PO4 buffer pH=6.0 / 240 h / 30 °C / Phaeocreopsis sp. JSM 1880 4: 1.) Ph3P, diethylazodicarboxylate, diphenylphosphoryl azide, 2.) LiAlH4 / 1.) THF, RT, 24 h, 2.) THF, reflux, 1 h 5: 92 percent / toluene / 18 h / Ambient temperature 6: 90 percent / H2 / 5percent Pd/C / ethanol / 5 h / 60 °C / 15200 - 19000 Torr View Scheme