3-甲基苯并呋喃-2-甲酸甲酯合成路线 （共 21 条）
反应条件
1: copper(l) chloride; pyridine / 1,2-dichloro-ethane / 48 h / 20 °C / |Molecular sieve 2: hydrazine hydrate / methanol; chloroform / 20 °C 3: sodium carbonate / ethyl acetate; water / 2 h / 0 °C 4: [{(η5-C5Me5)RhCl}2(μ-Cl)2]; caesium acetate; acetic acid / dichloromethane / 16 h / 20 °C View Scheme
参考文献
Liu, Guixia; Shen, Yangyang; Zhou, Zhi; Lu, Xiyan
Angewandte Chemie - International Edition, 2013 , vol. 52, # 23 p. 6033 - 6037
Angew. Chem., 2013 , vol. 125, # 23 p. 6149 - 6153,5
反应条件
1: hydrazine hydrate / methanol; chloroform / 20 °C 2: sodium carbonate / ethyl acetate; water / 2 h / 0 °C 3: [{(η5-C5Me5)RhCl}2(μ-Cl)2]; caesium acetate; acetic acid / dichloromethane / 16 h / 20 °C View Scheme
参考文献
Liu, Guixia; Shen, Yangyang; Zhou, Zhi; Lu, Xiyan
Angewandte Chemie - International Edition, 2013 , vol. 52, # 23 p. 6033 - 6037
Angew. Chem., 2013 , vol. 125, # 23 p. 6149 - 6153,5
反应条件
in methanol; chloroform
参考文献
Dorsey; McDonough; McDaniel; Levin; Newton; Hoffman; Darke; Zugay-Murphy; Emini; Schleif; Olsen; Stahlhut; Rutkowski; Kuo; Lin; Chen; Michelson; Holloway; Huff; Vacca
Journal of Medicinal Chemistry, 2000 , vol. 43, # 18 p. 3386 - 3399
反应条件
1: sodium carbonate / ethyl acetate; water / 2 h / 0 °C 2: [{(η5-C5Me5)RhCl}2(μ-Cl)2]; caesium acetate / methanol / 16 h / 20 °C View Scheme
参考文献
Liu, Guixia; Shen, Yangyang; Zhou, Zhi; Lu, Xiyan
Angewandte Chemie - International Edition, 2013 , vol. 52, # 23 p. 6033 - 6037
Angew. Chem., 2013 , vol. 125, # 23 p. 6149 - 6153,5
反应条件
1: copper(l) chloride; pyridine / 1,2-dichloro-ethane / 48 h / 20 °C / |Molecular sieve 2: hydrazine hydrate / methanol; chloroform / 20 °C 3: sodium carbonate / ethyl acetate; water / 2 h / 0 °C 4: [{(η5-C5Me5)RhCl}2(μ-Cl)2]; caesium acetate / methanol / 16 h / 20 °C View Scheme
参考文献
Liu, Guixia; Shen, Yangyang; Zhou, Zhi; Lu, Xiyan
Angewandte Chemie - International Edition, 2013 , vol. 52, # 23 p. 6033 - 6037
Angew. Chem., 2013 , vol. 125, # 23 p. 6149 - 6153,5
反应条件
1: hydrazine hydrate / methanol; chloroform / 20 °C 2: sodium carbonate / ethyl acetate; water / 2 h / 0 °C 3: [{(η5-C5Me5)RhCl}2(μ-Cl)2]; caesium acetate / methanol / 16 h / 20 °C View Scheme
参考文献
Liu, Guixia; Shen, Yangyang; Zhou, Zhi; Lu, Xiyan
Angewandte Chemie - International Edition, 2013 , vol. 52, # 23 p. 6033 - 6037
Angew. Chem., 2013 , vol. 125, # 23 p. 6149 - 6153,5
反应条件
1: tetrachloromethane; N-bromo-succinimide / auch unter Zusatz von Dibenzoylperoxid 2: quinoline 3: aqueous methanol. NaOH-solution 4: diethyl ether View Scheme
参考文献
Grubenmann; Erlenmeyer
Helvetica Chimica Acta, 1948 , vol. 31, p. 78,80
反应条件
1: quinoline 2: aqueous methanol. NaOH-solution 3: diethyl ether View Scheme
参考文献
Grubenmann; Erlenmeyer
Helvetica Chimica Acta, 1948 , vol. 31, p. 78,80
反应条件
1: aqueous methanol. NaOH-solution 2: diethyl ether View Scheme
参考文献
Grubenmann; Erlenmeyer
Helvetica Chimica Acta, 1948 , vol. 31, p. 78,80
反应条件
1: 87 percent / DIBAL / hexane; tetrahydrofuran / 1 h / Ambient temperature 2: 65 percent / MnO2 / benzene / Ambient temperature View Scheme
参考文献
Saari, Walfred S.; Wai, John S.; Fisher, Thorsten E.; Thomas, Craig M.; Hoffman, Jacob M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3792 - 3802
