外消旋5-羟甲基去异丙基托特罗定-d6合成路线 （共 69 条）
反应条件
1.1: dichloromethane / 20 h / 20 °C / |Inert atmosphere 2.1: water; sodium hydroxide / dichloromethane / pH 7 - 8 2.2: 0 - 25 °C View Scheme
反应条件
1.1: sulfuric acid; iron sulphate heptahydrate; sodium peroxodisulphate; dimethyl sulfoxide / water; acetonitrile / 2.5 h / 30 - 80 °C / |Large scale 1.2: 2.5 h / 30 °C / |Large scale 2.1: sodium tetrahydroborate; water; sodium hydroxide / acetonitrile / 3.67 h / 25 - 30 °C / |Large scale 3.1: palladium 10 on activated carbon; hydrogen / methanol / 6 h / 20 °C / 2250.23 - 3750.38 Torr / |Inert atmosphere; |Autoclave; |Large scale View Scheme
反应条件
1: sodium hydroxide / water; tert-butyl methyl ether / 2 h / 25 - 30 °C / |Large scale 2: palladium 10 on activated carbon; hydrogen / methanol / 6 h / 20 °C / 2250.23 - 3750.38 Torr / |Inert atmosphere; |Autoclave; |Large scale View Scheme
反应条件
potassium carbonate in tetrahydrofuran; ethanol T=0 - 20°C; Inert atmosphere;
参考文献
US2012/149772 A1, ;
Page/Page column 5 ;
反应条件
sodium hydroxide in water; toluene T=20°C; Inert atmosphere; Product distribution / selectivity;
参考文献
US2011/105783 A1, ;
Page/Page column 6 ;
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=-10 - -5°C; 2.5 h; Product distribution / selectivity;
参考文献
WO2007/140986 A1, ;
Page/Page column 12-14 ;
反应条件
1.1: sodium hydrogencarbonate / dichloromethane; water / 0.5 h / 0 - 5 °C / Inert atmosphere 2.1: sodium acetate / ethyl acetate; water / 0.5 h / 25 - 30 °C / autoclave 2.2: 12 h / 25 - 30 °C / 2206.72 - 2942.29 Torr View Scheme
参考文献
WO2012/98560 A2, ;
WO 2012/098560 A2
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=-10 - -5°C; 2.5 h; Product distribution / selectivity;
参考文献
SCHWARZ PHARMA LTD
Patent: WO2007/140986 A1, 2007 ;
Location in patent: Page/Page column 12-14 ;
反应条件
in acetone
T=20°C; 0.5 h;
参考文献
Meese, Claus O
Patent: US2003/212292 A1, 2003 ;
Location in patent: Page/Page column 9 ;
