2-羟基-2-(4-溴苯基)丙烷合成路线 （共 29 条）
反应条件
1: conc. HCl / CH2Cl2 / 5 h / Ambient temperature 2: 96 percent / pyridine / 21 h / Ambient temperature View Scheme
参考文献
Creary, Xavier; Aldridge, Timothy
Journal of Organic Chemistry, 1991 , vol. 56, # 13 p. 4280 - 4285
反应条件
1: 81 percent / TsOH / benzene / Heating
2: 85 percent / dimethyldioxirane
View Scheme
参考文献
Suprun, Wladimir
Advanced Synthesis and Catalysis, 1996 , vol. 338, # 3 p. 231 - 237
反应条件
diethylamino-sulfur trifluoride in dichloromethane
T=-78 - 20°C;
参考文献
Merck Sharp and Dohme Corp.
Patent: EP2102201 B1, 2010 ;
Location in patent: Page/Page column 41 ;
EP 2102201 B1
反应条件
perchloric acid in acetic acid
Ambient temperatureaddition of hydroquinone;
参考文献
Vilenskaya, M. R.; Petrovskaya, G. A.; Pokhmurskaya, M. V.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, p. 841 - 843
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 5 p. 959 - 961
反应条件
1: 4-bromo-α,α-dimethylbenzenemethanol With n-butyllithium in tetrahydrofuran; hexanes
T=-78°C; 3.5 h;
2: tri-isopropoxy-borane in tetrahydrofuran; hexanes
T=20°C; 72 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2006/48727 A1, 2006 ;
Location in patent: Page/Page column 75-76 ;
WO 2006/048727 A1
反应条件
phosphoric acid in benzene
5 h; Heating;
参考文献
Fraenkel,G.; Geckle,J.M.
Journal of the American Chemical Society, 1980 , vol. 102, p. 2869
反应条件
2,4-dinitrobenzenesulfonic acid hydrate in acetonitrile
T=80°C; 24 h; Title compound not separated from byproducts.;
参考文献
Sanz, Roberto; Martinez, Alberto; Guilarte, Veronica; Alvarez-Gutierrez, Julia M.; Rodriguez, Felix
European Journal of Organic Chemistry, 2007 , # 28 p. 4642 - 4645
反应条件
perchloric acid in acetic acid
Ambient temperature;
参考文献
Vilenskaya, M. R.; Petrovskaya, G. A.; Pokhmurskaya, M. V.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, p. 841 - 843
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 5 p. 959 - 961
反应条件
pyridinium bromide perbromide; 1,1,1,3,3,3-hexamethyl-disilazane in chloroform
0.5 h;
参考文献
Dawson; Jong; Hobbs; Cameron; Chao; Pfahl; Lee -; Shroot
Journal of Medicinal Chemistry, 1995 , vol. 38, # 17 p. 3368 - 3383
