1: 98 percent / NaHCO3 / toluene / 2.5 h / 86 °C 2: 78 percent / H2 / 10percent Pd/C / ethyl acetate / Ambient temperature 3: 1) Ba(OH)2*8H2O, 2) H2SO4 / 1) water, room temp., 2) <10 degC -> room temp., overnight 4: AG 50-X4(H+) / 120 h / Ambient temperature 6: 51 percent / pyridine / refrigerator, overnight 7: 87 percent / AG 1-X4(OH-) / methanol / 2 h / Ambient temperature 8: 81 percent / NaN3, NH4Cl / 2-methoxy-ethanol; H2O / 2 h / 100 °C 9: 330 mg / pyridine / 6 h / 0 °C 10: 170 mg / dimethylformamide / 28 h / 135 °C View Scheme

1: 98 percent / NaHCO3 / toluene / 2.5 h / 86 °C 2: 78 percent / H2 / 10percent Pd/C / ethyl acetate / Ambient temperature 3: 1) Ba(OH)2*8H2O, 2) H2SO4 / 1) water, room temp., 2) <10 degC -> room temp., overnight 4: AG 50-X4(H+) / 120 h / Ambient temperature 6: 51 percent / pyridine / refrigerator, overnight View Scheme

1: 98 percent / NaHCO3 / toluene / 2.5 h / 86 °C 2: 78 percent / H2 / 10percent Pd/C / ethyl acetate / Ambient temperature 3: 1) Ba(OH)2*8H2O, 2) H2SO4 / 1) water, room temp., 2) <10 degC -> room temp., overnight 4: AG 50-X4(H+) / 120 h / Ambient temperature 6: 51 percent / pyridine / refrigerator, overnight 7: 87 percent / AG 1-X4(OH-) / methanol / 2 h / Ambient temperature 8: 81 percent / NaN3, NH4Cl / 2-methoxy-ethanol; H2O / 2 h / 100 °C 9: H2 / 10percent Pd/C / methanol / 15 h / 2280 Torr View Scheme

1: 98 percent / NaHCO3 / toluene / 2.5 h / 86 °C 2: 78 percent / H2 / 10percent Pd/C / ethyl acetate / Ambient temperature 3: 1) Ba(OH)2*8H2O, 2) H2SO4 / 1) water, room temp., 2) <10 degC -> room temp., overnight 4: AG 50-X4(H+) / 120 h / Ambient temperature 6: 51 percent / pyridine / refrigerator, overnight 7: 87 percent / AG 1-X4(OH-) / methanol / 2 h / Ambient temperature 8: 81 percent / NaN3, NH4Cl / 2-methoxy-ethanol; H2O / 2 h / 100 °C 9: 330 mg / pyridine / 6 h / 0 °C 10: 170 mg / dimethylformamide / 28 h / 135 °C 11: 46 percent / 0.1 N NaOH / methanol; H2O / 6.5 h / Ambient temperature View Scheme

1: 98 percent / NaHCO3 / toluene / 2.5 h / 86 °C 2: 78 percent / H2 / 10percent Pd/C / ethyl acetate / Ambient temperature 3: 1) Ba(OH)2*8H2O, 2) H2SO4 / 1) water, room temp., 2) <10 degC -> room temp., overnight 4: AG 50-X4(H+) / 120 h / Ambient temperature 6: 51 percent / pyridine / refrigerator, overnight 7: 87 percent / AG 1-X4(OH-) / methanol / 2 h / Ambient temperature 8: 81 percent / NaN3, NH4Cl / 2-methoxy-ethanol; H2O / 2 h / 100 °C 9: 330 mg / pyridine / 6 h / 0 °C View Scheme

1: 98 percent / NaHCO3 / toluene / 2.5 h / 86 °C 2: 78 percent / H2 / 10percent Pd/C / ethyl acetate / Ambient temperature 3: 1) Ba(OH)2*8H2O, 2) H2SO4 / 1) water, room temp., 2) <10 degC -> room temp., overnight 4: AG 50-X4(H+) / 120 h / Ambient temperature 6: 51 percent / pyridine / refrigerator, overnight 7: 87 percent / AG 1-X4(OH-) / methanol / 2 h / Ambient temperature 8: 81 percent / NaN3, NH4Cl / 2-methoxy-ethanol; H2O / 2 h / 100 °C View Scheme