1-溴-3-苯基-2-丙酮合成路线 （共 21 条）
反应条件
hydrogen bromide; bromine; acetic acid in acetone 76 h;
参考文献
Sheppeck, James; Dhar, T.G. Murali; Doweyko, Lidia; Gilmore, John; Weinstein, David; Xiao, Hai-Yun; Yang, Bingwei V.; Doweyko, Arthur M.
Patent: US2006/154973 A1, 2006 ;
Location in patent: Page/Page column 34 ;
反应条件
hydrogen bromide in hexane; acetic acid; acetonitrile
参考文献
3-Dimensional Pharmaceuticals, Inc.
Patent: US6291514 B1, 2001 ;
反应条件
1: With boron trifluoride diethyl etherate in dichloromethane T=-20°C; 0.0833333 h; 2: With water; sodium hydrogencarbonate in dichloromethane optical yield given as percent destereoselective reaction;
参考文献
Cresswell, Alexander J.; Davies, Stephen G.; Lee, James A.; Roberts, Paul M.; Russell, Angela J.; Thomson, James E.; Tyte, Melloney J.
Organic Letters, 2010 , vol. 12, # 13 p. 2936 - 2939
反应条件
(i), (ii) HBr; Multistep reaction;
参考文献
Lohrisch, Hans-Joachim; Kopanski, Lothar; Herrmann, Rupert; Schmidt, Holger; Steglich, Wolfgang
Liebigs Annalen der Chemie, 1986 , # 1 p. 177 - 194
反应条件
1: With bromine in acetic acid T=20°C; 6 h; 2: With acetone T=20°C; 30 h;
参考文献
Choi, Han Young; Chi, Dae Yoon
Organic Letters, 2003 , vol. 5, # 4 p. 411 - 414
反应条件
sodium bromite in water; acetic acid 5 h; Ambient temperature; Yields of byproduct given;
参考文献
Kageyama, Toshifumi; Tobito, Yoshimichi; Katoh, Atsushi; Ueno, Yoshio; Okawara, Makoto
Chemistry Letters, 1983 , p. 1481 - 1482
反应条件
bromine in tetrachloromethane 1.) -20 deg C, 2.) room temperature; Yields of byproduct given;
参考文献
Benneche, Tore; Christiansen, Mette L.; Undheim, Kjell
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 8 p. 700 - 702
反应条件
hydrogen bromide in diethyl ether T=70 - 80°C; 1 h;
参考文献
Gangjee, Aleem; Yang, Jie; Ihnat, Michael A.; Kamat, Shekhar
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5155 - 5170
反应条件
1: SOCl2 / benzene / 1 h / Heating 2: diethyl ether / 1 h / 20 °C 3: 0.63 g / aq. HBr / diethyl ether / 1 h / 70 - 80 °C View Scheme
参考文献
Gangjee, Aleem; Yang, Jie; Ihnat, Michael A.; Kamat, Shekhar
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5155 - 5170
反应条件
1: diethyl ether / 1 h / 20 °C 2: 0.63 g / aq. HBr / diethyl ether / 1 h / 70 - 80 °C View Scheme
参考文献
Gangjee, Aleem; Yang, Jie; Ihnat, Michael A.; Kamat, Shekhar
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5155 - 5170
