反应条件
1: 1.24 g / KH, dibenzo-18-crown-6 / tetrahydrofuran / 7 h / Ambient temperature 2: 624 mg / 9 percent HCl-MeOH / 2 h / Ambient temperature 3: Et3N / 1.) Et2O, RT, 8 h, 2.) Et2O, water, reflux, 2 h 4: 2.) Ag2CO3 / 1.) CHCl3, iso-PrOH-DMF, 50 deg C, 2 h, 2.) reflux, 1 h 5: 81 mg / hydrogen / 10 percent Pd-C / methanol / 8 h / Ambient temperature 6: 59 mg / pyridine / 10 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 5 p. 1166 - 1169
