4-溴吡啶-2-氨基甲酸叔丁酯合成路线 （共 8 条）
反应条件
1: 4-bromo-2-pyridinecarboxylic acid With diphenyl phosphoryl azide; triethylamine in toluene T=20°C; 0.5 h; 2: tert-butyl alcohol in toluene T=90°C; 2 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/9465 A1, 2008 ;
Location in patent: Page/Page column 44 ;
US 20080009465 A1
参考文献
CURIS, INC.
Patent: WO2008/57497 A2, 2008 ;
Location in patent: Page/Page column 293 ;
反应条件
in tert-butyl alcohol T=50°C;
参考文献
WO2014/418 A1, ;
Page/Page column 30; 31 ;
反应条件
diphenylphosphoranyl azide; triethylamine 26 h; Heating;
参考文献
Deady, Leslie W.; Korytsky, Olga L.; Rowe, Jeffrey E.
Australian Journal of Chemistry, 1982 , vol. 35, # 10 p. 2025 - 2034
反应条件
1: With water; hydrogen bromide 16 h; 2: With sodium hydrogencarbonate in water
参考文献
CURIS, INC.
Patent: WO2008/57497 A2, 2008 ;
Location in patent: Page/Page column 301 ;
反应条件
hydrogenchloride in 1,4-dioxane T=20°C; 20 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/9465 A1, 2008 ;
Location in patent: Page/Page column 44 ;
US 20080009465 A1
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in dimethyl sulfoxide T=85°C; 1.25 h; Inert atmosphere;
参考文献
PFIZER LIMITED; ICAGEN, INC.; GREENER, Benjamin Scott; MARRON, Brian Edward; MILLAN, David Simon; RAWSON, David James; STORER, Robert Ian; SWAIN, Nigel Alan
Patent: WO2012/4714 A2, 2012 ;
Location in patent: Page/Page column 62 ;
WO 2012/004714 A2
反应条件
1: tert-butyl N-(4-bromo-2-pyridyl)carbamate With sodium hydride in tetrahydrofuran
T=0°C; 0.25 h;
2: methyl iodide in tetrahydrofuran
T=0 - 20°C; 16 h;
参考文献
CURIS, INC.
Patent: WO2008/57497 A2, 2008 ;
Location in patent: Page/Page column 296-297 ;
