1: (R)-2-phenyloxirane With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in tetrahydrofuran
T=-98°C; 0.166667 h;
2: methyl iodide in tetrahydrofuran
T=-98 - 20°C; Further stages.;
参考文献
Capriati, Vito; Florio, Saverio; Luisi, Renzo; Salomone, Antonio
Organic Letters, 2002 , vol. 4, # 14 p. 2445 - 2448
1: With trimethylaluminum in toluene
T=-60 - 20°C; 5.83333 h; Cooling with acetone-dry ice;
2: With sodium sulfate in tetrahydrofuran; water
T=20°C; 1.5 h;
参考文献
Aikins, James Abraham; Fray, Andrew Hendley; Miller, William David; Ornstein, Paul Leslie; Zarrinmayeh, Hamideh; Zimmerman, Dennis Michael
Patent: US2003/233015 A1, 2003 ;
Location in patent: Page 13 ;
1: in toluene
T=-60 - 20°C; 5.83333 h; Under nitrogenCooling with acetone-dry ice;
2: With water in tetrahydrofuran; toluene
0.5 h;
参考文献
Arnold, Macklin Brian; Bleisch, Thomas John; Cuff, George William; Ornstein, Paul Leslie; Zimmerman, Dennis Michael
Patent: US2003/225163 A1, 2003 ;
Location in patent: Page 13-14 ;
