sulfuric acid T=70°C; 0.25 h;

1: 83 percent / hydroxylamine hydrochloride; sodium sulfate; aq. HCl / 55 °C 2: 80 percent / conc. sulfuric acid / 55 - 80 °C View Scheme

1: hydroxylamine hydrochloride / water / 4 h / 40 - 75 °C 2: sulfuric acid / water / 75 - 80 °C View Scheme

palladium diacetate; cesium fluoride in ethylene glycol dimethyl ether; water Suzuki coupling; 3 h; Reflux;

1: With dihydrogen peroxide; sodium hydroxide in water T=20°C; 2: With hydrogenchloride in water pH=2;

1: methyl L-N-Boc-3-iodo-4-methoxyphenyl alanate; hexamethylditin With tetrakis(triphenylphosphine) palladium(0) in toluene Heating; 2: 7-iodo-1H-indole-2,3-dione With 1,1'-bis-(diphenylphosphino)ferrocene; copper(l) iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in N,N-dimethyl-formamide T=100°C; Stille coupling; 10 h;

1: 2-tert-butoxycarbonylamino-3-(3-iodo-4-methoxymethoxy-phenyl)-propionic acid methyl ester; hexamethylditin With tetrakis(triphenylphosphine) palladium(0) in toluene Heating; 2: 7-iodo-1H-indole-2,3-dione With copper(l) iodide; triphenyl-arsane; bis(benzonitrile)palladium(II) dichloride in N,N-dimethyl-formamide T=100°C; Stille coupling; 1 h;

sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether Suzuki coupling; Heating;

1: 55 percent / Pd(PPh3)4; NaHCO3 / 1,2-dimethoxy-ethane; H2O / 5 h / Heating 2: 72 percent / aq. NaOH; aq. H2O2 / 0.5 h / 50 °C View Scheme