2-羧甲基-5-三氟甲基苯甲酸合成路线 （共 3 条）
反应条件
1: 83 percent / CuBr, NaOMe / 24 h / 70 °C 2: NaOH / methanol; H2O / 3 h / Ambient temperature 3: ethyl acetate / 6 h / 65 °C View Scheme
参考文献
Quallich, George J.; Makowski, Teresa W.; Sanders, Andrew F.; Urban, Frank J.; Vazquez, Enrique
Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 4116 - 4119
反应条件
1: NaOH / methanol; H2O / 3 h / Ambient temperature 2: ethyl acetate / 6 h / 65 °C View Scheme
参考文献
Quallich, George J.; Makowski, Teresa W.; Sanders, Andrew F.; Urban, Frank J.; Vazquez, Enrique
Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 4116 - 4119
反应条件
1: 1.34 g / LiAlH4 / tetrahydrofuran / 16 h / Heating 2: Et3N / CH2Cl2 / 0.5 h / below 0 deg C 3: NH3 / tetrahydrofuran / 60 h / -78 - 24 °C / 6205.8 Torr View Scheme
参考文献
Quallich, George J.; Makowski, Teresa W.; Sanders, Andrew F.; Urban, Frank J.; Vazquez, Enrique
Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 4116 - 4119
