1-氯-2-丙-2-烯氧基苯合成路线 （共 29 条）
反应条件
1.1: 1,3,5-trimethyl-benzene / 48 h / 190 °C / |Inert atmosphere
2.1: borane-THF / tetrahydrofuran / 15 h / 20 °C
2.2: 1.75 h / 20 °C
3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 15 h / 0 °C / |Inert atmosphere
View Scheme
参考文献
CHDI FOUNDATION, INC.; TOLEDO-SHERMAN, Leticia, M; DOMINGUEZ, Celia; PRIME, Michael; MITCHELL, William, Leonard; JOHNSON, Peter; WENT, Naomi
Patent: WO2013/151707 A1, 2013 ;
反应条件
Sm(III) chloride; tetra-n-butylammonium tetrafluoroborate in N,N-dimethyl-formamide
8 h; Ambient temperatureelectrolysis (Mg anode, Ni foam cathode, constant current 100 mA);
参考文献
Espanet; Dunach; Perichon
Tetrahedron Letters, 1992 , vol. 33, # 18 p. 2485 - 2488
反应条件
sodium tetrahydroborate; 10-methyl-9,10-dihydroacridine in N,N-dimethyl-formamide
Irradiation;
参考文献
Boisvert, Guy; Giasson, Richard
Tetrahedron Letters, 1992 , vol. 33, # 44 p. 6587 - 6590
反应条件
tetra-n-butylammonium perchlorate in acetonitrile
T=25 - 30°C; Title compound not separated from byproducts;
参考文献
Kimura, Makoto; Miyahara, Hiroyoshi; Moritani, Noriyuki; Sawaki, Yasuhiko
Journal of Organic Chemistry, 1990 , vol. 55, p. 3897 - 3902
反应条件
acetone
T=20°C; 16 h; UV-irradiation;
参考文献
Dichiarante, Valentina; Fagnoni, Maurizio; Mella, Mariella; Albini, Angelo
Chemistry - A European Journal, 2006 , vol. 12, # 14 p. 3905 - 3915
反应条件
tetra-n-butylammonium perchlorate; zinc in N,N-dimethyl-formamide
T=25 - 30°C; also other cathodes, other solvents, other electrolytes; also addition of D2O; Product distributionMechanism;
参考文献
Kimura, Makoto; Miyahara, Hiroyoshi; Moritani, Noriyuki; Sawaki, Yasuhiko
Journal of Organic Chemistry, 1990 , vol. 55, p. 3897 - 3902
反应条件
toluene-4-sulfonic acid in 1,2-dichloro-ethane
0.666667 h; Heating;
参考文献
Tamura, Y.; Choi, H.-D.; Shindo, H.; Uenishi, J.; Ishibashi, H.
Tetrahedron Letters, 1981 , vol. 22, p. 81 - 84
反应条件
water; acetone in acetonitrile
T=20°C; 16 h; UV-irradiation;
参考文献
Dichiarante, Valentina; Fagnoni, Maurizio; Mella, Mariella; Albini, Angelo
Chemistry - A European Journal, 2006 , vol. 12, # 14 p. 3905 - 3915
反应条件
1: 0.17 h / 245 - 250 °C
2: m-chloroperbenzoic acid / CH2Cl2 / 24 h / 10 - 20 °C
3: Kieselgel 60 / CH2Cl2 / 24 h / Ambient temperature
4: Jones' reagent / acetone / 48 h / Ambient temperature
5: thionyl chloride / benzene / 2.5 h / Heating
6: NH3 / dioxane / 2 h / Ambient temperature
7: P2O5 / toluene / 2 h / Heating
8: 1.) NaOCH3 / 1.) CH3OH, 2 h, 2.) CH3OH, 0 - 5 deg C, 0.25 h
View Scheme
参考文献
Chapleo, Christopher B.; Myers, Peter L.; Butler, Richard C. M.; Davis, John A.; Doxey, John C.; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 570 - 576
