5-氯-3-氟-2-吡啶羧酸合成路线 （共 9 条）
反应条件
1: 5-chloro-3-fluoro-2-iodopyridine With n-butyllithium in hexane; toluene T=-75°C; 1 h; 2: carbon dioxide in hexane; toluene
参考文献
European Journal of Organic Chemistry, , # 24 p. 4174 - 4180
反应条件
1: 2-bromo-5-chloro-3-fluoropyridine With n-butyllithium in hexane; toluene T=-75°C; 1 h; 2: carbon dioxide in hexane; toluene
参考文献
European Journal of Organic Chemistry, , # 24 p. 4174 - 4180
反应条件
1.1: 91 percent / aq. sodium hydroxide / 20 h / 75 °C 2.1: 97 percent / phosphoryl tribromide / dimethylformamide / 2 h / 130 °C 3.1: 2 equiv. butyllithium / toluene; hexane / 1 h / -75 °C 3.2: 71 percent / toluene; hexane View Scheme
参考文献
European Journal of Organic Chemistry, , # 24 p. 4174 - 4180
反应条件
1.1: 97 percent / phosphoryl tribromide / dimethylformamide / 2 h / 130 °C 2.1: 2 equiv. butyllithium / toluene; hexane / 1 h / -75 °C 2.2: 71 percent / toluene; hexane View Scheme
参考文献
European Journal of Organic Chemistry, , # 24 p. 4174 - 4180
反应条件
1.1: butyllithium; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran / 0.25 h / -75 °C 1.2: methanol 2.1: 2 equiv. butyllithium / toluene; hexane / 1 h / -75 °C 2.2: 71 percent / toluene; hexane View Scheme
参考文献
European Journal of Organic Chemistry, , # 24 p. 4174 - 4180
反应条件
1.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / 0 °C 1.2: 59 percent / iodine / tetrahydrofuran / 1 h / -75 °C 2.1: 2 equiv. butyllithium / toluene; hexane / 1 h / -75 °C 2.2: 94 percent / toluene; hexane View Scheme
参考文献
European Journal of Organic Chemistry, , # 24 p. 4174 - 4180
反应条件
1.1: butyllithium; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran / 0.25 h / -75 °C 1.2: methanol 2.1: 2 equiv. butyllithium / toluene; hexane / 1 h / -75 °C 2.2: 94 percent / toluene; hexane View Scheme
参考文献
European Journal of Organic Chemistry, , # 24 p. 4174 - 4180
反应条件
1.1: triethylamine / tetrahydrofuran / 0.33 h / -25 - -15 °C 2.1: water; sodium tetrahydroborate / 18 h / 20 °C 2.2: pH ~ 7 View Scheme
参考文献
IRONWOOD PHARMACEUTICALS, INC.; HUDSON, Colleen; BARDEN, Timothy, C.; JIA, James; MERMERIAN, Ara; PENG, Bo; YANG, Jane; YU, Xiang, Y.; SPROTT, Kevin
Patent: WO2012/88469 A1, 2012 ;
WO 2012/088469 A1
反应条件
thionyl chloride in hexane; toluene
参考文献
Syngenta Crop Protection, Inc.
Patent: US6274536 B1, 2001 ;
