反应条件
1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C
2.1: tetrahydrofuran / 2 h / -78 - 20 °C
3.1: titanium(IV) isopropylate; ammonia / methanol / |Reflux
3.2: 3 h / 0 - 20 °C
View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; AMREIN, Kurt; HORNSPERGER, Benoit; KNUST, Henner; KUHN, Bernd; LIU, Yongfu; MAERKI, Hans P.; MAYWEG, Alexander V.; MOHR, Peter; TAN, Xuefei; ZHOU, Mingwei
Patent: WO2013/37779 A1, 2013 ;