5-氯-3,1-苯并噁嗪-2,4-二酮合成路线 （共 19 条）
反应条件
1: NaH / dimethylformamide / 5 h / 20 °C 2: NaH / dimethylformamide / 5 h / 85 °C View Scheme
参考文献
Joensson, Stig; Andersson, Gunnar; Fex, Tomas; Fristedt, Tomas; Hedlund, Gunnar; Jansson, Karl; Abramo, Lisbeth; Fritzson, Ingela; Pekarski, Olga; Runstroem, Anna; Sandin, Helena; Thuvesson, Ingela; Bjoerk, Anders
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 2075 - 2088
反应条件
1: NaH / dimethylformamide / 5 h / 20 °C 2: NaH / dimethylformamide / 5 h / 85 °C 3: 91 percent / HCl / acetic acid / 6 h / 60 °C View Scheme
参考文献
Wennerberg, Johan; Bjoerk, Anders; Fristedt, Tomas; Granquis, Bo; Jansson, Karl; Thuvesson, Ingela
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 674 - 680
反应条件
1: NaH / dimethylformamide / 5 h / 20 °C 2: NaH / dimethylformamide / 5 h / 85 °C 3: 91 percent / HCl / acetic acid / 6 h / 60 °C 4: 87 percent / SOCl2; Et3N / CH2Cl2 / 4.5 h / 0 - 20 °C View Scheme
参考文献
Wennerberg, Johan; Bjoerk, Anders; Fristedt, Tomas; Granquis, Bo; Jansson, Karl; Thuvesson, Ingela
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 674 - 680
反应条件
ethanol; ammonia
T=20°C; 2 h;
参考文献
RVX Therapeutics Inc.; McLure, Kevin G.; Young, Peter R.
Patent: US2013/281398 A1, 2013 ;
Location in patent: Paragraph 0490 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 72 h; Inert atmosphereLarge scale; Reagent/catalyst;
参考文献
Wennerberg, Johan; Bjoerk, Anders; Fristedt, Tomas; Granquis, Bo; Jansson, Karl; Thuvesson, Ingela
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 674 - 680
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=0 - 30°C; Inert atmosphere;
参考文献
Grue-Sorensen, Gunnar; Liang, Xifu; Mansson, Kristoffer; Vedso, Per; Dahl Sorensen, Morten; Soor, Anke; Stahlhut, Martin; Bertelsen, Malene; Engell, Karen Margrethe; Hoegberg, Thomas
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 54 - 60
反应条件
1: With sodium hydride in N,N-dimethyl acetamide; mineral oil
T=45°C; Inert atmosphere;
2: With methyl iodide in N,N-dimethyl acetamide; mineral oil
T=20°C; 2 h; Inert atmosphere; Time;
参考文献
Wennerberg, Johan; Bjoerk, Anders; Fristedt, Tomas; Granquis, Bo; Jansson, Karl; Thuvesson, Ingela
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 674 - 680
反应条件
sodium hydride in isobutyramide
T=5 - 85°C; 22 h;
参考文献
ACTIVE BIOTECH AB
Patent: WO2003/106424 A1, 2003 ;
Location in patent: Page 5 ;
反应条件
1: iPr2NEt / N,N-dimethyl-acetamide / 3 h / 40 °C
2: 1.36 g / NaO-t-Bu / N,N-dimethyl-acetamide / 1 h / 95 °C
View Scheme
参考文献
Beutner, Gregory L.; Kuethe, Jeffrey T.; Yasuda, Nobuyoshi
Journal of Organic Chemistry, 2007 , vol. 72, # 18 p. 7058 - 7061
