1-甲基-2-氧代-1,2-二氢吡啶-4-羧酸甲酯合成路线 （共 10 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
AstraZeneca AB; NPS PHARMACEUTICALS, INC.
Patent: US2007/259862 A1, 2007 ;
Location in patent: Page/Page column 29 ;
US 20070259862 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 72 h;
参考文献
ASTRAZENECA AB
Patent: WO2008/41075 A1, 2008 ;
Location in patent: Page/Page column 65 ;
WO 2008/041075 A1
反应条件
1: 4-carbomethoxy-2-hydroxypyridine With sodium hydride in N,N-dimethyl-formamide 0.5 h; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 16 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2007/67836 A2, 2007 ;
Location in patent: Page/Page column 102-103 ;
WO 2007/067836 A2
反应条件
1.1: potassium hydroxide; water / 36 h / 0 °C / |Reflux 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C 2.2: 0 - 20 °C View Scheme
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
反应条件
1: thionyl chloride / 1.5 h / Heating 2: 0.5 h / Heating View Scheme
参考文献
Deady, Leslie W.
Australian Journal of Chemistry, 1985 , vol. 38, # 4 p. 637 - 641
参考文献
Deady, Leslie W.
Australian Journal of Chemistry, 1985 , vol. 38, # 4 p. 637 - 641
反应条件
lithium hydroxide hydrate; water in methanol T=20°C; 2 h;
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
Location in patent: Paragraph 0229 ;
反应条件
potassium chloride; water T=25°C; Rate constant;
参考文献
Deady, Leslie W.
Australian Journal of Chemistry, 1985 , vol. 38, # 4 p. 637 - 641
反应条件
ethanol; hydrazine T=78°C; 3 h;
参考文献
ASTRAZENECA AB
Patent: WO2008/41075 A1, 2008 ;
Location in patent: Page/Page column 65 ;
WO 2008/041075 A1
反应条件
1: 50.5 percent / o-xylene / 96 h / 190 °C
2: 37.9 percent / 10 percent Pd/asbestos / various solvent(s) / 15 h / Heating
View Scheme
参考文献
Tomisawa, Hiroshi; Fujita, Reiko; Kato, Hideki; Hayasaka, Kazuhiko; Kamimura, Taiki; Hongo, Hiroshi
Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 5 p. 1882 - 1885
