反应条件
1: (2-chloroethyl)-benzene With iodine; zinc in N,N-dimethyl acetamide
T=80°C;
2: chloroacetyl chloride With tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl acetamide
T=20°C;
参考文献
Kaila, Neelu; Janz, Kristin; Huang, Adrian; Moretto, Alessandro; DeBernardo, Silvano; Bedard, Patricia W.; Tam, Steve; Clerin, Valerie; Keith Jr., James C.; Tsao, Desiree H.H.; Sushkova, Natalia; Shaw, Gray D.; Camphausen, Raymond T.; Schaub, Robert G.; Wang, Qin
Journal of Medicinal Chemistry, 2007 , vol. 50, # 1 p. 40 - 64