hydrogenchloride in tetrahydrofuran 22 h;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11342937', constants.ctx, '0')">potassium hydroxide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '506008', constants.ctx, '0')">dimethyl sulfoxide</a> <br />1.5&nbsp;h;&nbsp;&nbsp;Ambient temperature;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 1) TFA, 2) LiAlH₄ / 1) 0 deg C, 22 h, r.t., 3 h, 2) Et₂O, reflux, 14 h<br />2: 89 percent / KOH / dimethylsulfoxide / 1.5 h / Ambient temperature<br /> <br /> &nbsp;