1: (3,4-methylenedioxy)-6-methylbenzyl chloride With magnesium in tetrahydrofuran
T=8 - 45°C; 0.0333333 - 0.05 h;
2: [(3,4-methylendioxy)phenyl]methyl chloride in tetrahydrofuran
T=8°C; 1.5 h;
3: N-(4-chloro-3-methyl-5-isoxazolyl)-2-(N-methyl-N'-methoxy)aminocarbonyl-3-thiophenesulfonamide With hydrogenchloride
more than 3 stages;
参考文献
ENCYSIVE PHARMACEUTICALS, INC.
Patent: WO2007/106494 A2, 2007 ;
Location in patent: Page/Page column 39-40 ;
