反应条件
1: 1.) LDA, hexamethylphosphoramide / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, RT, overnight
2: triethylamine / H2O; acetone / 0 °C
3: NaN3 / H2O; acetone / 0.75 h / Ambient temperature
4: toluene / 0.5 h / Heating
5: Heating
6: H2 / ethanol / 24 h / 1810.02 Torr
View Scheme
参考文献
Nichols, David E.; Lloyd, David H.; Hoffman, Andrew J.; Nichols, Maxine B.; Yim, George K. W.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 5 p. 530 - 535
