3-甲基-2-(3,4-二甲氧基苯基)丁腈合成路线 （共 13 条）
反应条件
sodium hydroxide in water; dimethyl sulfoxide T=20°C; 48 h;
参考文献
Wang, Cheng; Wang, Tao; Zhou, Nan; Pan, Xiao-Yan; He, Huai-Zhen
Journal of Asian Natural Products Research, 2014 , vol. 16, # 3 p. 304 - 311
反应条件
potassium hydroxide; sodium hydroxide; hydroxylamine hydrochloride; potassium tert-butylate; sodium acetate; acetic anhydride in methanol; water; acetic acid; toluene
参考文献
Alfa Chemicals Italiana S.r.l.
Patent: EP285890 A2, 1988 ;
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; water
参考文献
G. D. Searle and Co.
Patent: US4681970 A1, 1987 ;
反应条件
indium tribromide in dichloromethane T=20°C; Inert atmosphere;
参考文献
Chen, Gang; Wang, Zheng; Wu, Jiang; Ding, Kuiling
Organic Letters, 2008 , vol. 10, # 20 p. 4573 - 4576
反应条件
sodium hydroxide; triethylamine in water
反应条件
1: 1.) NaH / 1.) DMF, 80 deg C, 5 h, 2.) 80 deg C, 20 h 2: 100 percent / NaOH / methanol; H2O / 22 h / Heating View Scheme
参考文献
Wang, Cheng; Wang, Tao; Zhou, Nan; Pan, Xiao-Yan; He, Huai-Zhen
Journal of Asian Natural Products Research, 2014 , vol. 16, # 3 p. 304 - 311
反应条件
1: sodium t-butanolate / tert-butyl alcohol / 3.5 h / 20 - 25 °C / |Large scale 2: potassium hydroxide / ethanol; water / |Large scale 3: ethyl acetate / 2 h / 60 - 65 °C / |Large scale 4: 3-nitro-phenyl boronic acid / anhydrous xylene / 24 h / 40 °C / |Reflux 5: dimethylsulfide borane complex / tetrahydrofuran / 16 h / 0 - 25 °C View Scheme
参考文献
Bannister, Robin M.; Brookes, Michael H.; Evans, Graham R.; Katz, Ruth B.; Tyrrell, Nicholas D.
Organic Process Research and Development, 2000 , vol. 4, # 6 p. 467 - 472
反应条件
1: 70 percent / NaNH2 / toluene / 5 h / Heating 2: oxalic acid / acetone; H2O / 3 h / 40 °C View Scheme
参考文献
Butora, Gabriel; Blaha, Ludvik; Rajsner, Miroslav; Helfert, Ivan
Collection of Czechoslovak Chemical Communications, 1992 , vol. 57, # 9 p. 1967 - 1981
反应条件
N-benzyl-N,N,N-triethylammonium chloride; potassium in tetrahydrofuran 36 h; Heating;
参考文献
European Journal of Medicinal Chemistry, , vol. 25, # 4 p. 351 - 359
