5-硝基-2-甲基硫代吡啶合成路线 （共 16 条）
反应条件
triethylamine in methanol T=20°C; 2 h;
参考文献
ELI LILLY AND COMPANY; BLEISCH, Thomas, John; COATES, David, Andrew; HUGHES, Norman, Earle; JONES, Scott, Alan; NORMAN, Bryan, Hurst
Patent: WO2013/66640 A1, 2013 ;
Location in patent: Page/Page column 18 ;
反应条件
monosodium carbonate in ethanol; water T=20°C; 1 h;
参考文献
Pfizer Inc.
Patent: US6649636 B1, 2003 ;
Location in patent: Page/Page column 52 ;
反应条件
triethylamine in methanol 2 h; Ambient temperature;
参考文献
Takemoto; Eda; Okada; Sakashita; Matzno; Gohda; Ebisu; Nakamura; Fukaya; Hihara; Eiraku; Yamanouchi; Yokoyama
Journal of Medicinal Chemistry, 1994 , vol. 37, # 1 p. 18 - 25
参考文献
Pfizer Inc.
Patent: US6531492 B1, 2003 ;
Title/Abstract Full Text Show Details
Cheng, Hengmiao; Sakya, Subas Man; Dutra, Jason Kenneth
Patent: US2002/58681 A1, 2002 ;
反应条件
in N,N-dimethyl-formamide
参考文献
Krauss, Nancy Elisabeth; Mirzadegan, Taraneh; Smith, David Bernard; Walker, Keith Adrian
Patent: US2002/52349 A1, 2002 ;
反应条件
in sodium hydroxide; water
参考文献
Boehringer Ingelheim GmbH
Patent: US4415566 A1, 1983 ;
反应条件
1: Na2S*9H2O / dimethylformamide / 1 h / 20 °C 2: dimethylformamide / 24 h / 20 °C View Scheme
参考文献
Takahashi; Saikati
Yakugaku Zasshi, 1942 , vol. 62, p. 140,142; dtsch. Ref. S. 44, 45
Chem.Abstr., 1951 , p. 1592
反应条件
in N,N-dimethyl-formamide T=20°C; 24 h; Yield given;
参考文献
Bourdais; Dauvillier; Gayral; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 3 p. 233 - 239
参考文献
Takahashi; Saikati
Yakugaku Zasshi, 1942 , vol. 62, p. 140,142; dtsch. Ref. S. 44, 45
Chem.Abstr., 1951 , p. 1592
反应条件
in DMF (N,N-dimethyl-formamide)
参考文献
CJ CORPORATION
Patent: WO2004/48367 A1, 2004 ;
Location in patent: Page 11 ;
