ethylenediaminetetraacetic acid; Tris buffer; papain T=25°C; pH= 7.5;

sodium hydrogencarbonate in water T=20°C; pH=8.4; 1 h;

hydrogenchloride; sodium tetrahydroborate; caesium carbonate 1.) CH3CN, room temp., 2 h, 2.) EtOH, 0 deg C, 0.5 h, 3.) 10 min; Yield givenMultistep reaction;

1: 96 percent / sodium hydrogen carbonate / ethanol; H2O / 6 h / Heating 2: 100 percent / zinc; ammonium chloride / methanol / 4 h / 20 - 75 °C 3: 70 percent / benzotriazolyloxy-tris-(dimethylamino)phosphonium PF6-; sodium hydrogen carbonate / dimethylformamide / 20 °C 4: 77 percent / potassium hydroxide; tetrabutylammonium iodide / tetrahydrofuran / 0 - 20 °C 5: 97 percent / sodium hydroxide / ethanol; H2O / 2 h / 20 °C View Scheme

[bis(acetoxy)iodo]benzene in dichloromethane 0.0833333 h; Ambient temperature;

phosphate buffer in acetone 2 h; 1.) pH= 8, 2.) pH= 3;

sodium hydroxide in water; acetonitrile T=20°C; pH=11-12; Inert atmosphere;