3-氨基-5-(4-异丁基苯基)噻吩-2-羧酸甲酯合成路线 (共 1 条)
反应条件
1: 1-(4-[2-methylpropyl]-phenyl)-ethanone; N,N-dimethyl-formamide With trichlorophosphate T=20°C; 2: With hydroxylamine hydrochloride T=0 - 100°C; 3: 2-mercaptoacetic acid methyl ester With sodium methylate in N,N-dimethyl-formamide T=0°C; Further stages.;
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 24 p. 7095 - 7107