2,5-二氨基-苯磺酰胺合成路线 （共 13 条）
反应条件
1: ammonia 2: palladium 10 on activated carbon; hydrazine hydrate / ethanol / 1.5 h / Reflux 3: 0.5 h / 180 °C 4: sulfuric acid; nitric acid / 21 h / 0 - 20 °C 5: sulfuric acid / 130 °C 6: palladium 10 on activated carbon; hydrogen / tetrahydrofuran / 5 h / 25 °C / 760.05 Torr View Scheme
参考文献
Ismail, Mohamed A.H.; Abou El Ella, Dalal A.; Abouzid, Khaled A.M.; Mahmoud, Amr H.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5647 - 5647
反应条件
1: pyridine / 120 °C 2: ammonium hydrogen carbonate; copper(II) sulfate / 120 °C / |Autoclave 3: hydrogen; palladium 10 on activated carbon / tetrahydrofuran / 5 h / 25 °C / 760.05 Torr View Scheme
参考文献
Ismail, Mohamed A.H.; Abou El Ella, Dalal A.; Abouzid, Khaled A.M.; Mahmoud, Amr H.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5647 - 5647
反应条件
1.1: pyridine / dichloromethane / 0 - 23 °C / Industry scale
2.1: tetrahydrofuran / 1 h / 0 - 23 °C / Industry scale
3.1: sodium hydroxide; water / 30 h / 23 °C / Industry scale
3.2: 0 °C / Industry scale
View Scheme
参考文献
ANADYS PHARMACEUTICALS, INC.
Patent: WO2008/124450 A1, 2008 ;
