1: 2-bromo-α,α,α-trifluorotoluene With magnesium in tetrahydrofuran 0.833333 h; Heating / reflux; 2: 1-Phenylmethyl-piperidin-4-one in tetrahydrofuran T=0 - 20°C; 3 h; 3: With ammonium chloride in tetrahydrofuran; water

1: 2-bromo-α,α,α-trifluorotoluene With iodine; magnesium in tetrahydrofuran Grignard reaction; Inert atmosphereReflux; 2: 1-Phenylmethyl-piperidin-4-one in tetrahydrofuran T=20°C; Grignard reaction; 3 h; Inert atmosphereCooling with ice;

1: hydrogenchloride / 9 h / Reflux 2: hydrogenchloride / diethyl ether; ethyl acetate 3: palladium 10 on activated carbon; hydrogen / methanol / 12 h View Scheme