(2-氰基苯基)乙酸甲酯合成路线 （共 15 条）
参考文献
Journal of Organic Chemistry, , vol. 18, p. 30,33
反应条件
1: H2; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr 2: Et3N / tetrahydrofuran / 25 °C 3: aq. LiOH / tetrahydrofuran / 25 °C View Scheme
参考文献
Le Bourdonnec, Bertrand; Ajello, Christopher W.; Seida, Pamela R.; Susnow, Roberta G.; Cassel, Joel A.; Belanger, Serge; Stabley, Gabriel J.; DeHaven, Robert N.; DeHaven-Hudkins, Diane L.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2647 - 2652
反应条件
1: H2; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr 2: Et3N / tetrahydrofuran / 25 °C View Scheme
参考文献
Le Bourdonnec, Bertrand; Ajello, Christopher W.; Seida, Pamela R.; Susnow, Roberta G.; Cassel, Joel A.; Belanger, Serge; Stabley, Gabriel J.; DeHaven, Robert N.; DeHaven-Hudkins, Diane L.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2647 - 2652
反应条件
hydrogenchloride; hydrogen; palladium 10 on activated carbon; carbon; palladium in methanol T=20°C; P=3620.13 Torr;
参考文献
Le Bourdonnec, Bertrand; Ajello, Christopher William; Dolle, Roland E.
Patent: US2004/254156 A1, 2004 ;
Location in patent: Page 16 ;
反应条件
1: sodium hydroxide; tetrabutylammomium bromide / water; toluene / 1 h / 20 °C
2: palladium 10 on activated carbon; hydrogen / ethanol / 3 h / 20 °C / 1520.1 Torr
3: sodium hydroxide / water; methanol / 0.5 h / 20 °C
4: sulfuric acid; potassium nitrate / 20 °C
5: boron trifluoride diethyl etherate; sodium tetrahydroborate / tetrahydrofuran / 2 h / |Reflux
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; SHUMWAY, Stuart Denham; TONIATTI, Carlo; ROBERTS, Brian Scott; MARTIN, Melissa M.
Patent: WO2013/39854 A1, 2013 ;
