2,3-二氢-4-硝基-1H-茚-2-羧酸合成路线 （共 5 条）
反应条件
1: With water; sodium hydroxide in 1,4-dioxane T=50°C; 2 h; 2: With hydrogenchloride in 1,4-dioxane; water pH=1; Reflux;
参考文献
BAYER SCHERING PHARMA AKTIEGESELLSCHAFT
Patent: US2011/34450 A1, 2011 ;
Location in patent: Page/Page column 47; 48 ;
反应条件
nitric acid; trifluoroacetic acid in water T=0°C; 5.16667 h;
参考文献
Hay, Michael P.; Hicks, Kevin O.; Pchalek, Karin; Lee, Ho H.; Blaser, Adrian; Pruijn, Frederik B.; Anderson, Robert F.; Shinde, Sujata S.; Wilson, William R.; Denny, William A.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 21 p. 6853 - 6865
反应条件
1.1: potassium carbonate / acetonitrile / Reflux 2.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 50 °C 2.2: pH 1 / Reflux View Scheme
参考文献
BAYER SCHERING PHARMA AKTIEGESELLSCHAFT
Patent: US2011/34450 A1, 2011 ;
反应条件
1: methanol With thionyl chloride
T=-10°C; 0.166667 h;
2: 4-nitro-2-indanecarboxylic acid T=20°C; 3 h;
参考文献
BAYER SCHERING PHARMA AKTIEGESELLSCHAFT
Patent: US2011/34450 A1, 2011 ;
Location in patent: Page/Page column 48 ;
反应条件
1.1: thionyl chloride / 0.17 h / -10 °C
1.2: 3 h / 20 °C
2.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 22 h / 20 °C
View Scheme
参考文献
BAYER SCHERING PHARMA AKTIEGESELLSCHAFT
Patent: US2011/34450 A1, 2011 ;
