(9ci)-2,3-二氢-5-硝基-1H-茚-2-羧酸合成路线 （共 7 条）
反应条件
conc. nitric acid; sulfuric acid
参考文献
H. Lundbeck A/S
Patent: US6262087 B1, 2001 ;
反应条件
1: diethyl malonate With sodium hydride in diethyl ether
T=20°C; 0.5 h;
2: 1,2-Bis-bromomethyl-4-nitro-benzene T=20°C; 24 h;
3: With hydrogenchloride; sodium hydroxide
more than 3 stages;
参考文献
AUCKLAND UNISERVICES LIMITED
Patent: WO2006/104406 A1, 2006 ;
Location in patent: Page/Page column 109 ;
反应条件
nitric acid; trifluoroacetic acid in water
T=0°C; 5.16667 h;
参考文献
AUCKLAND UNISERVICES LIMITED
Patent: WO2006/104406 A1, 2006 ;
Location in patent: Page/Page column 113 ;
反应条件
sodium hydroxide; ethanol; water
T=20°C; 15 h;
参考文献
Hay, Michael P.; Hicks, Kevin O.; Pchalek, Karin; Lee, Ho H.; Blaser, Adrian; Pruijn, Frederik B.; Anderson, Robert F.; Shinde, Sujata S.; Wilson, William R.; Denny, William A.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 21 p. 6853 - 6865
反应条件
1: nitric acid / 0 °C
2: beim Erhitzen ueber den Schmelzpunkt
View Scheme
参考文献
Mills; Parker; Prowse
Journal of the Chemical Society, 1914 , vol. 105, p. 1542
反应条件
methoxybenzene
inactive form;
参考文献
Mills; Parker; Prowse
Journal of the Chemical Society, 1914 , vol. 105, p. 1542
参考文献
Mills; Parker; Prowse
Journal of the Chemical Society, 1914 , vol. 105, p. 1542
