反应条件
1: acetic acid; N-iodo-succinimide / 20 °C 2: tetrakis(triphenylphosphine) palladium(0); N-ethyl-N,N-diisopropylamine; copper(l) iodide / 70 °C / |Inert atmosphere 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 75 °C 4: potassium sec-butoxide / tetrahydrofuran / 3 h / 75 °C View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim
Patent: WO2013/26914 A1, 2013 ;
WO 2013/026914 A1