3-甲氧基-2(1H)-吡啶酮合成路线 （共 17 条）
反应条件
1: 3-Hydroxy-2(1H)-pyridinone With sodium hydroxide in water T=20°C; 0.166667 h; 2: dimethyl sulfate in water T=0 - 20°C;
参考文献
WO2008/101682 A2, ;
Page/Page column 65 ;
反应条件
sodium hydroxide in water T=20°C; 3 h;
参考文献
Hanessian, Stephen; Saavedra, Oscar M; Mascitti, Vincent; Marterer, Wolfgang; Oehrlein, Reinhold; Mak, Ching-Pong
Tetrahedron, 2001 , vol. 57, # 16 p. 3267 - 3280
反应条件
1: 90 percent / POCl3, PCl5 / 1 h / 140 °C 2: 90 percent / Pd(PPh3)4 / dioxane; hexane / 5.5 h / Heating 3: 90 percent / NaBO3 / acetic acid / 5.5 h / 80 °C 4: POCl3 / 1 h / Heating View Scheme
参考文献
Ohta, Akihiro; Takahashi, Nobuhiro; Shirokoma, Yasuko
Heterocycles, 1990 , vol. 30, # 2 p. 875 - 884
反应条件
1: 90 percent / POCl3, PCl5 / 1 h / 140 °C 2: 90 percent / Pd(PPh3)4 / dioxane; hexane / 5.5 h / Heating 3: 90 percent / NaBO3 / acetic acid / 5.5 h / 80 °C 4: POCl3 / 1 h / Heating View Scheme
参考文献
Ohta, Akihiro; Takahashi, Nobuhiro; Shirokoma, Yasuko
Heterocycles, 1990 , vol. 30, # 2 p. 875 - 884
反应条件
sulfuric acid; nitric acid T=0 - 40°C; 3 h;
参考文献
Gruenenthal GmbH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo
Patent: US2013/29962 A1, 2013 ;
Location in patent: Paragraph 0982 ;
反应条件
1: sulfuric acid; nitric acid / 3 h / 0 - 40 °C 2: trichlorophosphate; phosphorus pentachloride / 4 h / |Reflux View Scheme
参考文献
Gruenenthal GmbH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo
Patent: US2013/29962 A1, 2013 ;
反应条件
phosphorus pentachloride; trichlorophosphate T=140°C; 1 h;
参考文献
Ohta, Akihiro; Takahashi, Nobuhiro; Shirokoma, Yasuko
Heterocycles, 1990 , vol. 30, # 2 p. 875 - 884
反应条件
1: 90 percent / POCl3, PCl5 / 1 h / 140 °C 2: 90 percent / Pd(PPh3)4 / dioxane; hexane / 5.5 h / Heating 3: 90 percent / NaBO3 / acetic acid / 5.5 h / 80 °C 4: 15 percent / POCl3 / 1 h / Heating View Scheme
参考文献
Heterocycles, , vol. 30, # 2 p. 875 - 884
反应条件
methyllithium 1) THF, Et2O, 0 deg C, 20 min, 2) THF, Et2O, 16 h; Yield given. Multistep reaction;
参考文献
Posner, Gary H.; Vinader, Victoria; Afarinkia, Kamyar
Journal of Organic Chemistry, 1992 , vol. 57, # 15 p. 4088 - 4097
反应条件
1: potasium hydroxide / propan-1-ol 2: 63 percent / boron tribromide / CH2Cl2 / 24 h / -70 - 20 °C View Scheme
参考文献
Patil, Vishal; Sodji, Quaovi H.; Kornacki, James R.; Mrksich, Milan; Oyelere, Adegboyega K.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 9 p. 3492 - 3506
