1-甲基-1,4-二氢-2,3-喹喔啉二酮合成路线 （共 8 条）
参考文献
Usherwood; Whiteley
Journal of the Chemical Society, 1923 , vol. 123, p. 1082
反应条件
1: POCl3 / 1.5 h / Heating 2: hydrazine hydrate / ethanol / 1 h / Heating View Scheme
参考文献
Makino, Kenzi; Sakata, Gozyo; Morimoto, Katsushi
Heterocycles, 1985 , vol. 23, # 8 p. 2025 - 2034
参考文献
Usherwood; Whiteley
Journal of the Chemical Society, 1923 , vol. 123, p. 1082
反应条件
1: SOCl2 / toluene; dimethylformamide / 2 h / 130 °C
2: acetonitrile / 2 h / 120 °C
3: various solvent(s) / 0.42 h / 220 - 230 °C
View Scheme
参考文献
Loev; Musser; Brown; Jones; Kahen; Huang; Khandwala; Sonnino-Goldman; Leibowitz
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 363 - 366
反应条件
1: SOCl2 / toluene; dimethylformamide / 2 h / 130 °C
2: acetonitrile / 2 h / 120 °C
3: various solvent(s) / 0.42 h / 220 - 230 °C
4: pyridine / 3 h / 100 °C
View Scheme
参考文献
Loev; Musser; Brown; Jones; Kahen; Huang; Khandwala; Sonnino-Goldman; Leibowitz
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 363 - 366
反应条件
1: SOCl2 / toluene; dimethylformamide / 2 h / 130 °C
2: acetonitrile / 2 h / 120 °C
3: various solvent(s) / 0.42 h / 220 - 230 °C
4: NaH / dimethylformamide / 5 h / 60 °C
View Scheme
参考文献
Loev; Musser; Brown; Jones; Kahen; Huang; Khandwala; Sonnino-Goldman; Leibowitz
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 363 - 366
反应条件
N-ethyl-N,N-diisopropylamine; trichlorophosphate in toluene
T=110°C;
参考文献
Dudash Jr., Joseph; Zhang, Yongzheng; Moore, John B.; Look, Richard; Liang, Yin; Beavers, Mary Pat; Conway, Bruce R.; Rybczynski, Philip J.; Demarest, Keith T.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 21 p. 4790 - 4793
反应条件
potassium hydroxide; dimethyl sulfate
参考文献
Cheeseman
Journal of the Chemical Society, 1955 , p. 1804,1806
