2-(2,6-二氯苯基)-2-(6-(2,4-二氟苯基硫代)吡嗪-3-基)乙腈合成路线 （共 2 条）
反应条件
trans-1,2-cyclohexanediol; potassium carbonate in isopropyl alcohol T=120°C; Ullmann type coupling; 3 h; Microwave irradiation;
参考文献
Bagley, Mark C.; Davis, Terence; Dix, Matthew C.; Fusillo, Vincenzo; Pigeaux, Morgane; Rokicki, Michal J.; Kipling, David
Journal of Organic Chemistry, 2009 , vol. 74, # 21 p. 8336 - 8342
反应条件
1: 62 percent / potassium tert-butoxide / toluene / 1.5 h / 120 °C / microvawe irradiation 2: 75 percent / NaOtBu / PEPPSITM-IPr / toluene / 1 h / 150 °C / microvawe irradiation View Scheme
参考文献
Bagley, Mark C.; Davis, Terence; Dix, Matthew C.; Rokicki, Michal J.; Kipling, David
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 18 p. 5107 - 5110
