3-(5,6-二氢苯并[b][1]苯并氮杂卓-11-基)丙-1-胺合成路线 （共 10 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=50°C; 2 h;
2: With sodium hydroxide; water in tetrahydrofuran
T=0 - 20°C; 0.75 h;
参考文献
ALANTOS PHARMACEUTICALS, INC.
Patent: WO2006/116157 A2, 2006 ;
Location in patent: Page/Page column 65-66 ;
WO 2006/116157 A2
反应条件
hydrazine hydrate; sodium amide in anhydrous xylene; ethanol; ethyl acetate
参考文献
Smith Kline and French Laboratories Limited
Patent: US4668671 A1, 1987 ;
US 4668671 A
反应条件
lithium aluminium tetrahydride; aluminium trichloride in tetrahydrofuran; diethyl ether
1) r.t., 30 min, 2) reflux, 3.5 h;
参考文献
Hulinska, Hana; Polivka, Zdenek; Jilek, Jiri; Sindelar, Karel; Holubek, Jiri; et al.
Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 8 p. 1820 - 1844
反应条件
sodium tetrahydroborate in isopropyl alcohol
参考文献
Runyon, Scott P.; Savage, Jason E.; Taroua, Mohamed; Roth, Bryan L.; Glennon, Richard A.; Westkaemper, Richard B.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 5 p. 655 - 658
反应条件
1: BF3*THF
2: dimethylformamide
3: NaBH4 / propan-2-ol
View Scheme
参考文献
Runyon, Scott P.; Savage, Jason E.; Taroua, Mohamed; Roth, Bryan L.; Glennon, Richard A.; Westkaemper, Richard B.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 5 p. 655 - 658
反应条件
1: BF3*THF
2: dimethylformamide
3: NaBH4 / propan-2-ol
View Scheme
参考文献
Runyon, Scott P.; Savage, Jason E.; Taroua, Mohamed; Roth, Bryan L.; Glennon, Richard A.; Westkaemper, Richard B.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 5 p. 655 - 658
反应条件
1: dimethylformamide
2: NaBH4 / propan-2-ol
View Scheme
参考文献
Runyon, Scott P.; Savage, Jason E.; Taroua, Mohamed; Roth, Bryan L.; Glennon, Richard A.; Westkaemper, Richard B.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 5 p. 655 - 658
反应条件
1: T=37°C; 0.05 h; aq. phosphate bufferEnzymatic reaction;
2: With NADPH
aq. phosphate buffer;
参考文献
Hanson, Kelsey L.; VandenBrink, Brooke M.; Babu, Kantipudi N.; Allen, Kyle E.; Nelson, Wendel L.; Kunze, Kent L.
Drug Metabolism and Disposition, 2010 , vol. 38, # 6 p. 963 - 972
反应条件
1: T=37°C; 0.05 h; aq. phosphate bufferEnzymatic reaction;
2: With NADPH
aq. phosphate buffer;
参考文献
Hanson, Kelsey L.; VandenBrink, Brooke M.; Babu, Kantipudi N.; Allen, Kyle E.; Nelson, Wendel L.; Kunze, Kent L.
Drug Metabolism and Disposition, 2010 , vol. 38, # 6 p. 963 - 972
反应条件
1.1: sodium carbonate / methanol; water / 0 - 110 °C / Inert atmosphere
2.1: rat cytochrome P450 2C11 / 0.05 h / 37 °C / aq. phosphate buffer; Enzymatic reaction
2.2: aq. phosphate buffer
View Scheme
参考文献
Hanson, Kelsey L.; VandenBrink, Brooke M.; Babu, Kantipudi N.; Allen, Kyle E.; Nelson, Wendel L.; Kunze, Kent L.
Drug Metabolism and Disposition, 2010 , vol. 38, # 6 p. 963 - 972
