N-(4-氯苄基)-n-(4-甲氧基苯基)肼盐酸盐合成路线 (共 4 条)
反应条件
triethylamine in toluene 15 h; Heating;
参考文献
Riendeau, Denis; Aspiotis, Renee; Ethier, Diane; Gareau, Yves; Grimm, Erich L.; Guay, Jocelyne; Guiral, Sebastien; Juteau, Helene; Mancini, Joseph A.; Methot, Nathalie; Rubin, Joel; Friesen, Richard W.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3352 - 3355
反应条件
hydrogenchloride in 1,4-dioxane; diethyl ether; toluene T=0 - 20°C; 2 h;
参考文献
AMIRA PHARMACEUTICALS, INC.
Patent: WO2008/67566 A1, 2008 ;
Location in patent: Page/Page column 99 ;
反应条件
sodium acetate; acetic acid in toluene T=20°C; Fischer Indole Synthesis; 120 h;
参考文献
AMIRA PHARMACEUTICALS, INC.
Patent: WO2008/67566 A1, 2008 ;
Location in patent: Page/Page column 99 ;
反应条件
1: 68 percent / NaOAc, glacial AcOH / toluene / 72 h / Ambient temperature 2: 1 N LiOH / methanol; tetrahydrofuran / 3 h / 80 °C 3: 78 percent / tert-butylthiol, NaH, HMPA / 5 h / 175 °C View Scheme
参考文献
Hutchinson; Riendeau; Brideau; Chan; Delorme; Denis; Falgueyret; Fortin; Guay; Hamel; Jones; Macdonald; McFarlane; Piechuta; Scheigetz; Tagari; Therien; Girard
Journal of Medicinal Chemistry, 1993 , vol. 36, # 19 p. 2771 - 2787