4,6-二氯-2-苯基嘧啶-5-胺合成路线 （共 5 条）
反应条件
potassium carbonate; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide T=100°C; 24 h;
参考文献
Smithkline Beecham Corporation
Patent: US2008/242685 A1, 2008 ;
Location in patent: Page/Page column 17 ;
反应条件
iron; acetic acid in tetrahydrofuran 1.5 h; Heating;
参考文献
Biagi, Giuliana; Giorgi, Irene; Livi, Oreste; Pacchini, Federica; Rum, Pietro; Scartoni, Valerio; Costa, Barbara; Mazzoni, Maria Rosa; Giusti, Laura
Farmaco, 2002 , vol. 57, # 3 p. 221 - 233
参考文献
Biagi, Giuliana; Giorgi, Irene; Livi, Oreste; Nardi, Antonio; Pacchini, Federica; Scartoni, Valerio; Lucacchini, Antonio
European journal of medicinal chemistry, 2003 , vol. 38, # 11-12 p. 983 - 990
反应条件
1: 82 percent / NH3 gas / ethanol / 72 h / 110 °C
2: 53 percent / aq. acetic acid; KNO2 / tetrahydrofuran / 5 h / 0 - 20 °C
View Scheme
参考文献
Biagi, Giuliana; Giorgi, Irene; Livi, Oreste; Pacchini, Federica; Rum, Pietro; Scartoni, Valerio; Costa, Barbara; Mazzoni, Maria Rosa; Giusti, Laura
Farmaco, 2002 , vol. 57, # 3 p. 221 - 233
反应条件
1: Ac2O
2: 85 percent / NH3; N,N-diethylaniline / ethanol / 12 h / Heating
View Scheme
参考文献
Biagi, Giuliana; Giorgi, Irene; Livi, Oreste; Nardi, Antonio; Pacchini, Federica; Scartoni, Valerio; Lucacchini, Antonio
European journal of medicinal chemistry, 2003 , vol. 38, # 11-12 p. 983 - 990
