1-Boc-4-乙氧基羰基甲基哌嗪合成路线 （共 9 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 12 h;
参考文献
AFFINIUM PHARMACEUTICALS, INC.
Patent: WO2007/67416 A2, 2007 ;
Location in patent: Page/Page column 62; 128 ;
WO 2007/067416 A2
反应条件
triethylamine in dichloromethane T=22°C; 24 h;
参考文献
PFIZER INC.
Patent: WO2004/63198 A1, 2004 ;
Location in patent: Page 92 ;
WO 2004/063198 A1
反应条件
ruthenium trichloride T=20°C; 1.5 h; neat (no solvent);
参考文献
Varala, Ravi; Enugala, Ramu; Adapa, Srinivas R.
Monatshefte fur Chemie, 2008 , vol. 139, # 11 p. 1369 - 1372
反应条件
in hexane; dichloromethane; ethyl acetate
参考文献
US5977139 A1, ;
US 5977139 A
反应条件
N-benzyl-trimethylammonium hydroxide T=20°C; Neat (no solvent);
参考文献
Meshram; Reddy, B. Chennakesava; Goud, P. Ramesh
Synthetic Communications, 2009 , vol. 39, # 13 p. 2297 - 2303
反应条件
N-ethyl-N,N-diisopropylamine in pentane T=60°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 4 p. 723 - 728
反应条件
trifluoroacetic acid in dichloromethane
参考文献
VERNALIS (CAMBRIDGE) LIMITED; CANCER RESEARCH TECHNOLOGY LTD; THE INSTITUTE OF CANCER RESEARCH
Patent: WO2004/56782 A1, 2004 ;
Location in patent: Page 25 ;
反应条件
sodium hydroxide in methanol; water T=20°C; 2 h;
参考文献
WO2013/53983 A1, ;
Page/Page column 42 ;
反应条件
lithium hydroxide in tetrahydrofuran; chloroform; water; ethyl acetate
参考文献
US5977139 A1, ;
US 5977139 A
