1-BOC-4-(4-氯苯甲酰)哌啶合成路线 （共 7 条）
反应条件
triethylsilane in methanol T=20°C; Inert atmosphere;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; TAKEDA CAMBRIDGE LIMITED; CARROLL, Colm; GOLDBY, Anne; TEALL, Martin
Patent: WO2013/179024 A1, 2013 ;
Location in patent: Page/Page column 67-68 ;
反应条件
Dess-Martin periodane in dichloromethane T=20°C; 1.5 h;
参考文献
WO2004/5255 A1, ;
Page 42 ;
WO 2004/005255 A1
反应条件
1: AlCl3 / 1,2-dichloro-ethane / Heating 2: aq. HCl / Heating 3: aq. NaHCO3 / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 25 p. 5512 - 5532
反应条件
1: SOCl2 / 1 h / 20 °C 2: AlCl3 / 1,2-dichloro-ethane / Heating 3: aq. HCl / Heating 4: aq. NaHCO3 / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 25 p. 5512 - 5532
参考文献
US6187792 B1, ;
US 6187792 B1
反应条件
sodium hydrogencarbonate T=20°C;
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 25 p. 5512 - 5532
反应条件
1: aq. HCl / Heating 2: aq. NaHCO3 / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 25 p. 5512 - 5532
