6-苯基-4-羟基噻吩并[3,2-d]嘧啶合成路线 （共 5 条）
反应条件
1: With ammonium acetate 6 h; Heating / reflux; 2: With ammonium formate in formamide T=140°C; 10 h;
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: WO2009/7422 A1, 2009 ;
Location in patent: Page/Page column 33 ;
参考文献
Shah, Manish; Parikh, Khyati; Parekh, Hansa
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1998 , vol. 37, # 1 p. 73 - 77
反应条件
1: 63 percent / NaOEt / ethanol / 0.17 h / Heating 2: 86 percent / 6 h / 160 - 180 °C View Scheme
参考文献
Shah, Manish; Parikh, Khyati; Parekh, Hansa
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1998 , vol. 37, # 1 p. 73 - 77
反应条件
1: 1.) POCl3, 2.) NH2OH*HCl / 1.) 45-55 deg C, room temperature (30 min), 2.) 70-80 deg C, 160 deg C 2: 63 percent / NaOEt / ethanol / 0.17 h / Heating 3: 86 percent / 6 h / 160 - 180 °C View Scheme
参考文献
Shah, Manish; Parikh, Khyati; Parekh, Hansa
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1998 , vol. 37, # 1 p. 73 - 77
反应条件
dimethyl amine; trichlorophosphate 8 h; Heating;
参考文献
Shah, Manish; Parikh, Khyati; Parekh, Hansa
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1998 , vol. 37, # 1 p. 73 - 77
