(S)-(+)-2-苯甘氨醇合成路线 （共 103 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Heating;
参考文献
Feng, Dong-Zhi; Song, Yan-Li; Jiang, Xiao-Hua; Chen, Li; Long, Ya-Qiu
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 16 p. 2690 - 2697
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1.5 h; Reflux;
参考文献
Arvidsson, Per I.; Govender, Thavendran; Kruger, Hendrik G.; Maguire, Glenn E.M.; Naicker, Tricia
South African Journal of Chemistry, 2009 , vol. 62, p. 60 - 66
反应条件
sodium tetrahydroborate in ethanol 1) RT, 9h, b) 5.5h, reflux, c) RT, 8h;
参考文献
Chang, Zen-Yu; Coates, Robert M.
Journal of Organic Chemistry, 1990 , vol. 55, # 11 p. 3475 - 3483
反应条件
sulfuric acid in 1,4-dioxane T=70 - 80°C; 3 h;
参考文献
Synthesis, , # 8 p. 608 - 610
反应条件
hydrogen; palladium dihydroxide in methanol 0.25 h;
参考文献
Bravo, Pierfrancesco; Capelli, Silvia; Crucianelli, Marcello; Guidetti, Maurizia; Markovsky, Andrey L.; Meille, Stefano V.; Soloshonok, Vadim A.; Sorochinsky, Alexander E.; Viani, Fiorenza; Zanda, Matteo
Tetrahedron, 1999 , vol. 55, # 10 p. 3025 - 3040
反应条件
hydrogenchloride; (S)-3,3′-bis[3,5-bis(trifluoromethyl)phenyl]-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate in dichloromethane; water T=21.84°C; pH=2.32; Centrifugal contactor separatorsResolution of racemate; optical yield given as percent ee;
参考文献
Schuur, Boelo; Verkuijl, Bastiaan J.V.; Bokhove, Jeroen; Minnaard, Adriaan J.; De Vries, Johannes G.; Heeres, Hero J.; Feringa, Ben L.
Tetrahedron, 2011 , vol. 67, # 2 p. 462 - 470
反应条件
ammonium hydroxide in water T=130°C; P=9000.72 Torr; microwave irradiation;
参考文献
Tetrahedron Letters, , vol. 43, # 14 p. 2581 - 2584
反应条件
1: LiH / dimethylformamide 2: H2NOH*HCl; NaOAc / ethanol; H2O 3: Fe / dimethylformamide 4: 100 percent / H2 / {1,2-bis[(R,R)-2,5-dimethylphospholane]benzene}rhodium(I) / toluene / 20 °C / 7600 Torr 5: 81 percent / methanol / Acid hydrolysis View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 23 p. 8100 - 8101
参考文献
Bulletin of the Chemical Society of Japan, , vol. 55, # 4 p. 1188 - 1190
反应条件
1: 70 percent / DOWEX 50W X8-400 / benzene / Heating 2: LDA / tetrahydrofuran; hexane / -70 °C / 1.) 15 min, 2.) 30 min 3: 80 percent / CAN / H2O; acetonitrile / 0.5 h / 0 °C 4: 80 percent / K2CO3 / dioxane; H2O / 0.17 h / Ambient temperature 5: 1.) (CF3CO)2O, sym-collidine, 2.) K2CO3, NaBH4 / 1.) MeCN, 0 deg C, 5 min, 2.) H2O, 0 deg C to room temperature, 15 min 6: 80 percent / H2 / Pd(OH)2/C / methanol / 0.25 h View Scheme
参考文献
Tetrahedron, , vol. 55, # 10 p. 3025 - 3040
