(S)-(+)-2-苯甘氨醇合成路线 （共 103 条）
反应条件
1: 90 percent / NaHCO3 / CH2Cl2 / 20 °C
2: 98 percent / Et3N / CH2Cl2 / 0.33 h / 20 °C
3: 78 percent / NaN3, nBu4NBr / toluene; H2O / 85 - 90 °C
4: H2, MeOH-HCl / Pd/C / 24 h / 4654.3 Torr / Ambient temperature
View Scheme
参考文献
Hsiao, Yi; Hegedus, Louis S.
Journal of Organic Chemistry, 1997 , vol. 62, # 11 p. 3586 - 3591
反应条件
[RuH(tBu-PNP(-))(CO)] in toluene
T=165°C; 24 h; Inert atmosphereReflux;
参考文献
Gnanaprakasam, Boopathy; Balaraman, Ekambaram; Ben-David, Yehoshoa; Milstein, David
Angewandte Chemie - International Edition, 2011 , vol. 50, # 51 p. 12240 - 12244
反应条件
disodium hydrogenphosphate; iodine; sodium sulfate
T=65°C;
参考文献
Calvet, Sandrine; David, Olivier; Vanucci-Bacque, Corinne; Fargeau-Bellassoued, Marie-Claude; Lhommet, Gerard
Tetrahedron, 2003 , vol. 59, # 33 p. 6333 - 6339
