(S)-(+)-2-苯甘氨醇合成路线 （共 103 条）
反应条件
1: H2NOH*HCl; NaOAc / ethanol; H2O 2: Fe / dimethylformamide 3: 100 percent / H2 / {1,2-bis[(R,R)-2,5-dimethylphospholane]benzene}rhodium(I) / toluene / 20 °C / 7600 Torr 4: 81 percent / methanol / Acid hydrolysis View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 23 p. 8100 - 8101
反应条件
1: 100 percent / H2 / {1,2-bis[(R,R)-2,5-dimethylphospholane]benzene}rhodium(I) / toluene / 20 °C / 7600 Torr 2: 81 percent / methanol / Acid hydrolysis View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 23 p. 8100 - 8101
反应条件
in methanol Hydrolysis; Acid hydrolysis;
参考文献
Zhu; Casalnuovo; Zhang
Journal of Organic Chemistry, 1998 , vol. 63, # 23 p. 8100 - 8101
反应条件
1: NaBH4 / methanol 2: TFA / CH2Cl2 / 3 h / 20 °C 3: 0.136 g / H2 / Raney-Ni / methanol / 28 h / 25 °C / 25857.4 Torr View Scheme
参考文献
European Journal of Organic Chemistry, , # 20 p. 4585 - 4595
反应条件
1: TFA / CH2Cl2 / 3 h / 20 °C 2: 0.136 g / H2 / Raney-Ni / methanol / 28 h / 25 °C / 25857.4 Torr View Scheme
参考文献
European Journal of Organic Chemistry, , # 20 p. 4585 - 4595
反应条件
1: D-proline / CH2Cl2 / 3 h / 20 °C 2: NaBH4 / methanol 3: TFA / CH2Cl2 / 3 h / 20 °C 4: 0.136 g / H2 / Raney-Ni / methanol / 28 h / 25 °C / 25857.4 Torr View Scheme
参考文献
European Journal of Organic Chemistry, , # 20 p. 4585 - 4595
反应条件
1: With sodium tetrahydroborate; sulfuric acid in tetrahydrofuran; diethyl ether T=0 - 20°C; 20 h; Inert atmosphere; 2: With hydrogenchloride in water T=20°C; 2 h;
参考文献
Synthesis, , vol. 44, # 7 p. 1057 - 1062
反应条件
1: 80 percent / CAN / H2O; acetonitrile / 0.5 h / 0 °C 2: 80 percent / K2CO3 / dioxane; H2O / 0.17 h / Ambient temperature 3: 1.) (CF3CO)2O, sym-collidine, 2.) K2CO3, NaBH4 / 1.) MeCN, 0 deg C, 5 min, 2.) H2O, 0 deg C to room temperature, 15 min 4: 80 percent / H2 / Pd(OH)2/C / methanol / 0.25 h View Scheme
参考文献
Tetrahedron, , vol. 55, # 10 p. 3025 - 3040
反应条件
1: LDA / tetrahydrofuran; hexane / -70 °C / 1.) 15 min, 2.) 30 min 2: 80 percent / CAN / H2O; acetonitrile / 0.5 h / 0 °C 3: 80 percent / K2CO3 / dioxane; H2O / 0.17 h / Ambient temperature 4: 1.) (CF3CO)2O, sym-collidine, 2.) K2CO3, NaBH4 / 1.) MeCN, 0 deg C, 5 min, 2.) H2O, 0 deg C to room temperature, 15 min 5: 80 percent / H2 / Pd(OH)2/C / methanol / 0.25 h View Scheme
参考文献
Tetrahedron, , vol. 55, # 10 p. 3025 - 3040
反应条件
1: 80 percent / K2CO3 / dioxane; H2O / 0.17 h / Ambient temperature 2: 1.) (CF3CO)2O, sym-collidine, 2.) K2CO3, NaBH4 / 1.) MeCN, 0 deg C, 5 min, 2.) H2O, 0 deg C to room temperature, 15 min 3: 80 percent / H2 / Pd(OH)2/C / methanol / 0.25 h View Scheme
参考文献
Tetrahedron, , vol. 55, # 10 p. 3025 - 3040
