(S)-(+)-2-苯甘氨醇合成路线 （共 103 条）
反应条件
1: 1.) (CF3CO)2O, sym-collidine, 2.) K2CO3, NaBH4 / 1.) MeCN, 0 deg C, 5 min, 2.) H2O, 0 deg C to room temperature, 15 min 2: 80 percent / H2 / Pd(OH)2/C / methanol / 0.25 h View Scheme
参考文献
Tetrahedron, , vol. 55, # 10 p. 3025 - 3040
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran 6 h; RefluxInert atmosphere; 2: With sulfuric acid in tetrahydrofuran RefluxInert atmosphere;
参考文献
Organic Letters, , vol. 10, # 10 p. 2071 - 2074
反应条件
sodium hydroxide in water
参考文献
Organic Letters, , vol. 15, # 7 p. 1658 - 1661
反应条件
1.1: 85 percent / NaBH4; I2 / tetrahydrofuran / 4 h / Heating 2.1: dibenzoyl-L-tartaric acid / acetone / 6 h / 25 °C 2.2: aq. KOH / CH2Cl2 View Scheme
参考文献
Synthesis, , # 13 p. 1965 - 1967
反应条件
1: TiCl4 / 15 °C / Irradiation 2: H2 / S, Ram, L. D. Spicer Synth. Commun. 1987, 17, 415. View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 17 p. 2535 - 2536
反应条件
hydroxylammonium acetate in ethanol 20 h; Ambient temperature; Yield given;
参考文献
Synthetic Communications, , vol. 19, # 19 p. 3337 - 3342
反应条件
1: n-butyllithium / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 1.) -78 deg C, 2 h, 2.) RT, 0.5 h, 3.) -78 deg C, 0.5 h, 4.) -30 - -20 deg C, 10 h 2: hydroxylamine acetate / ethanol / 20 h / Ambient temperature View Scheme
参考文献
Synthetic Communications, , vol. 19, # 19 p. 3337 - 3342
反应条件
1: 76 percent / boron trifluoride etherate / benzene / 10 h / Heating 2: n-butyllithium / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 1.) -78 deg C, 2 h, 2.) RT, 0.5 h, 3.) -78 deg C, 0.5 h, 4.) -30 - -20 deg C, 10 h 3: hydroxylamine acetate / ethanol / 20 h / Ambient temperature View Scheme
参考文献
Synthetic Communications, , vol. 19, # 19 p. 3337 - 3342
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Heating; Yield given;
参考文献
Journal of the Chemical Society, Chemical Communications, , # 2 p. 95 - 97
反应条件
1: 100 percent / SOCl2 / CCl4 / Heating 2: 81 percent / LiN3 / dimethylformamide / 120 °C 3: LiAlH4 / tetrahydrofuran / Heating View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 2 p. 95 - 97
