(S)-(+)-2-苯甘氨醇合成路线 （共 103 条）
反应条件
1: 81 percent / LiN3 / dimethylformamide / 120 °C 2: LiAlH4 / tetrahydrofuran / Heating View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 2 p. 95 - 97
反应条件
trifluoroacetic acid in dichloromethane 1 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 16 p. 2519 - 2526
反应条件
hydrogen S, Ram, L. D. Spicer Synth. Commun. 1987, 17, 415.;
参考文献
Tetrahedron Letters, , vol. 39, # 17 p. 2535 - 2536
反应条件
lithium aluminium tetrahydride
参考文献
Farmaco, Edizione Scientifica, , vol. 8, p. 212,215
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C 2: sodium hydride / tetrahydrofuran; mineral oil / -10 - 20 °C View Scheme
参考文献
Hu, Pengfei; Hu, Jian; Jiao, Jiajun; Tong, Xiaofeng
Angewandte Chemie - International Edition, 2013 , vol. 52, # 20 p. 5319 - 5322
Angew. Chem., 2013 , vol. 125, # 20 p. 5427 - 5430,4
反应条件
1: 82 percent / toluene / Heating View Scheme
参考文献
Fray; Meyers
Journal of Organic Chemistry, 1996 , vol. 61, # 10 p. 3362 - 3374
反应条件
1.1: N-ethyl-N,N-diisopropylamine / 48 h / 135 °C / Inert atmosphere 2.1: methanesulfonyl chloride; triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere 2.2: 0.5 h / 20 °C / Inert atmosphere 2.3: 12 h / 55 °C / Inert atmosphere View Scheme
参考文献
Matsumoto, Takuya; Urano, Yasuteru; Takahashi, Yoshinori; Mori, Yusuke; Terai, Takuya; Nagano, Tetsuo
Journal of Organic Chemistry, 2011 , vol. 76, # 10 p. 3616 - 3625
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C 2: sodium hydride / tetrahydrofuran; mineral oil / -10 - 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 48 h / 0 °C / |Reflux View Scheme
参考文献
Hu, Pengfei; Hu, Jian; Jiao, Jiajun; Tong, Xiaofeng
Angewandte Chemie - International Edition, 2013 , vol. 52, # 20 p. 5319 - 5322
Angew. Chem., 2013 , vol. 125, # 20 p. 5427 - 5430,4
反应条件
1: With triethylamine in dichloromethane T=20°C; 3 h; 2: With methanesulfonyl chloride; triethylamine in dichloromethane T=0°C; 24 h;
参考文献
Kim, Hae-Jo; Asif, Riaz; Chung, Doo Soo; Hong, Jong-In
Tetrahedron Letters, 2003 , vol. 44, # 23 p. 4335 - 4338
反应条件
zinc trifluoromethanesulfonate in toluene 48 h; Heating;
参考文献
Cornejo; Fraile; Garcia; Gil; Martinez-Merino; Mayoral; Pires; Villalba
Synlett, 2005 , # 15 art. no. G13005ST, p. 2321 - 2324
