(S)-(+)-2-苯甘氨醇合成路线 （共 103 条）
反应条件
in dichloromethane 48 h; Heating;
参考文献
Meng, Jun-Cai; Fokin, Valery V.; Finn
Tetrahedron Letters, 2005 , vol. 46, # 27 p. 4543 - 4546
反应条件
potassium hydroxide in ethanol Heating;
参考文献
Shankaran; Donnelly, Karla L.; Shah, Shrenik K.; Guthikonda, Ravindra N.; MacCoss, Malcolm; Humes, John L.; Pacholok, Stephen G.; Grant, Stephan K.; Kelly; Wong
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4539 - 4544
反应条件
1: H2SO4 2: aq. NaOH View Scheme
参考文献
Dewey,C.S.; Bafford,R.A.
Journal of Organic Chemistry, 1965 , vol. 30, p. 491 - 495
反应条件
hydrogenchloride 1.) reflux, 1 h, 2.) CH2Cl2, room temp., overnight; Yield givenMultistep reaction;
参考文献
Katritzky, Alan R.; Cui, Xi-Lin; Yang, Baozhen; Steel, Peter J.
Journal of Organic Chemistry, 1999 , vol. 64, # 6 p. 1979 - 1985
反应条件
potassium carbonate in methanol T=20°C; Acylation;
参考文献
Lewanowicz; Lipinski; Siedlecka; Skarzewski; Baert
Tetrahedron, 1998 , vol. 54, # 23 p. 6571 - 6586
反应条件
in pyridine; dichloromethane T=0 - 20°C;
参考文献
Farras, Jaume; Ginesta, Xavier; Sutton, Peter W; Taltavull, Joan; Egeler, Frank; Romea, Pedro; Urpi, Felix; Vilarrasa, Jaume
Tetrahedron, 2001 , vol. 57, # 36 p. 7665 - 7674
反应条件
1: 1.) NaH / 1.) THF, reflux, 30 min, 2.) THF, reflux, 48 h 2: 85 percent / K2CO3 / tetrahydrofuran / 60 h / Heating 3: 68 percent / NaNH2, liq. NH3 / diethyl ether / 0.03 h View Scheme
参考文献
Ince, Julie; Ross, Tracey M.; Shipman, Michael; Ennis, David S.
Tetrahedron Asymmetry, 1996 , vol. 7, # 12 p. 3397 - 3406
反应条件
1: benzene / 2 h / Heating 2: m-CPBA / CH2Cl2 / 0.5 h / 0 °C 3: 10.8 g / NH2OH*HCl / methanol / 18 h / 20 °C 4: H2O; CH2Cl2 / 0.5 h / 20 °C / Heating 5: p-TsOH / CH2Cl2 / 2 h / Heating 6: 76 percent / benzene / 4 h / 20 °C 7: Mo(CO)6 / acetonitrile; H2O / 2 h / Heating View Scheme
参考文献
Tamura; Gotanda; Yoshino; Morita; Terashima; Kikuchi; Miyawaki; Mita; Yamashita; Ishibashi; Sakamoto
Journal of Organic Chemistry, 2000 , vol. 65, # 25 p. 8544 - 8551
反应条件
Escherichia coli penicillin acylase; potassium chloride in water T=24.84°C; pH=6.4; Enzymatic reaction; Equilibrium constant;
参考文献
Guranda, Dorel T.; Ushakov, Gennadij A.; Yolkin, Petr G.; Svedas, Vytas K.
Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 74, # 1-2 p. 48 - 53
反应条件
1: 66 percent / Na2HPO4 / tetrahydrofuran / 3 h / 25 °C 2: 75 percent / 6N NaOH / methanol / 0.25 h / 60 °C View Scheme
参考文献
Chang, Zen-Yu; Coates, Robert M.
Journal of Organic Chemistry, 1990 , vol. 55, # 11 p. 3464 - 3474
